Convergent Evolution at the Pathway Level: Predictable Regulatory Changes during Flower Color Transitions
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msy117
Abstract: The predictability of evolution, or whether lineages repeatedly follow the same evolutionary trajectories during phenotypic convergence remains an open question of evolutionary biology. In this study, we investigate evolutionary convergence at the biochemical pathway level… read more here.
Keywords: regulatory changes; evolution; evolution pathway; pathway level ... See more keywords
Neural Network Deconvolution Method for Resolving Pathway-Level Progression of Tumor Clonal Expression Programs With Application to Breast Cancer Brain Metastases
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2020.01055
Abstract: Metastasis is the primary mechanism by which cancer results in mortality and there are currently no reliable treatment options once it occurs, making the metastatic process a critical target for new diagnostics and therapeutics. Treating… read more here.
Keywords: pathway level; expression; deconvolution; cancer ... See more keywords
Pilot Study Showing Feasibility of Phosphoproteomic Profiling of Pathway-Level Molecular Alterations in Barrett’s Esophagus
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13071215
Abstract: (1) Background: Barrett’s esophagus is a major risk factor for esophageal adenocarcinoma. In this pilot study, we employed precision mass spectrometry to map global (phospho)protein perturbations in Barrett’s esophagus lesions and adjacent normal tissue to… read more here.
Keywords: barrett esophagus; feasibility; pilot study; pathway level ... See more keywords