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   Articles with "pathway level" as a keyword



Convergent Evolution at the Pathway Level: Predictable Regulatory Changes during Flower Color Transitions

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recommendations! Published in 2018 at "Molecular Biology and Evolution"

DOI: 10.1093/molbev/msy117

Abstract: The predictability of evolution, or whether lineages repeatedly follow the same evolutionary trajectories during phenotypic convergence remains an open question of evolutionary biology. In this study, we investigate evolutionary convergence at the biochemical pathway level… read more here.

Keywords: regulatory changes; evolution; evolution pathway; pathway level ... See more keywords

A Pathway-Level Information ExtractoR (PLIER) framework to gain mechanistic insights into obesity in Down syndrome

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recommendations! Published in 2024 at "Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing"

DOI: 10.1142/9789819807024_0030

Abstract: Down syndrome (DS), caused by the triplication of chromosome 21 (T21), is a prevalent genetic disorder with a higher incidence of obesity. Traditional approaches have struggled to differentiate T21-specific molecular dysregulation from general obesity-related processes.… read more here.

Keywords: level information; obesity; plier framework; pathway level ... See more keywords

Abstract 503: Tracking evolution of transcriptional landscapes during colorectal cancer development and progression

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recommendations! Published in 2025 at "Cancer Research"

DOI: 10.1158/1538-7445.am2025-503

Abstract: Colorectal cancer (CRC) has been classified into molecular subtypes using gene-level data from both bulk and single-cell RNA sequencing (scRNA-seq), leading to the development of the consensus molecular subtypes (CMS) and intrinsic CMS (iCMS). In… read more here.

Keywords: colorectal cancer; cancer; pathway level; tracking evolution ... See more keywords
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Neural Network Deconvolution Method for Resolving Pathway-Level Progression of Tumor Clonal Expression Programs With Application to Breast Cancer Brain Metastases

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recommendations! Published in 2020 at "Frontiers in Physiology"

DOI: 10.3389/fphys.2020.01055

Abstract: Metastasis is the primary mechanism by which cancer results in mortality and there are currently no reliable treatment options once it occurs, making the metastatic process a critical target for new diagnostics and therapeutics. Treating… read more here.

Keywords: pathway level; expression; deconvolution; cancer ... See more keywords

Pilot Study Showing Feasibility of Phosphoproteomic Profiling of Pathway-Level Molecular Alterations in Barrett’s Esophagus

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recommendations! Published in 2022 at "Genes"

DOI: 10.3390/genes13071215

Abstract: (1) Background: Barrett’s esophagus is a major risk factor for esophageal adenocarcinoma. In this pilot study, we employed precision mass spectrometry to map global (phospho)protein perturbations in Barrett’s esophagus lesions and adjacent normal tissue to… read more here.

Keywords: barrett esophagus; feasibility; pilot study; pathway level ... See more keywords