Why do pathway methods work better than they should?
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Letters"
DOI: 10.1002/1873-3468.14011
Abstract: Pathway analysis methods are frequently applied to cancer gene expression data to identify dysregulated pathways. These methods often infer pathway activity based on the expression of genes belonging to a given pathway, even though the… read more here.
Keywords: work better; methods work; expression; pathway methods ... See more keywords
Advances in the calculation of binding free energies.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in structural biology"
DOI: 10.1016/j.sbi.2020.01.016
Abstract: In recent years, calculations of binding affinities from molecular simulations seem to have matured significantly. While the number of applications of such methods in drug design and biotechnology increases, the number of truly new methodological… read more here.
Keywords: free energies; calculation binding; calculation; binding free ... See more keywords