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Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-14367-0
Abstract: The catalog of cancer driver mutations in protein-coding genes has greatly expanded in the past decade. However, non-coding cancer driver mutations are less well-characterized and only a handful of recurrent non-coding mutations, most notably TERT…
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Keywords:
pathway network;
analysis;
non coding;
coding mutations ... See more keywords
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Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac200
Abstract: Abstract Haploinsufficiency drives Darwinian evolution. Siblings, while alike in many aspects, differ due to monoallelic differences inherited from each parent. In cancer, solid tumors exhibit aneuploid genetics resulting in hundreds to thousands of monoallelic gene-level…
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Keywords:
pathway network;
network;
network identification;
identification common ... See more keywords
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Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000029107
Abstract: ABSTRACT Given the high disability rate of multiple sclerosis (MS), there is a need for safer and more effective therapeutic agents. Existing literature highlights the prominent roles of miRNA in MS pathophysiology. Nevertheless, there are…
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Keywords:
regulated drug;
drug;
mirna regulated;
drug pathway ... See more keywords
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Published in 2022 at "IEEE transactions on neural networks and learning systems"
DOI: 10.1109/tnnls.2022.3213374
Abstract: Recently, deep multi-view clustering (MVC) has attracted increasing attention in multi-view learning owing to its promising performance. However, most existing deep multi-view methods use single-pathway neural networks to extract features of each view, which cannot…
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Keywords:
pathway network;
multi;
multi view;
multi pathway ... See more keywords
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Published in 2018 at "BioMed Research International"
DOI: 10.1155/2018/5670210
Abstract: Biological pathways play important roles in the development of complex diseases, such as cancers, which are multifactorial complex diseases that are usually caused by multiple disorders gene mutations or pathway. It has become one of…
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Keywords:
analysis complex;
pathway network;
network;
complex diseases ... See more keywords
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Published in 2019 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2019.00835
Abstract: Non-functional pituitary adenoma (NFPA) seriously affects hypothanamus-pituitary-target organ axis system, with a series of molecule alterations in the multiple levels of genome, transcriptome, proteome, and post-translational modifications, and those molecules mutually interact in a molecular-network…
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Keywords:
functional pituitary;
pathway network;
network;
pathway ... See more keywords
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Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.1013737
Abstract: Osteosarcoma (OS) is a common bone cancer in children and adolescents, and metastasis and recurrence are the major causes of poor treatment outcomes. A better understanding of the tumor microenvironment is required to develop an…
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Keywords:
pathway network;
cell;
analysis;
signaling pathway ... See more keywords
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Published in 2019 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2019.10353
Abstract: As a common degenerative disease, osteoporosis (OS) is characterized by reduced bone mass and microarchitectural deterioration of bone tissue. Both genetic and environmental factors are involved in OS development. To date, ~300 genes have been…
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Keywords:
pathway network;
network;
genes related;
network analysis ... See more keywords