Pathway and network analysis of more than 2500 whole cancer genomes
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-14367-0
Abstract: The catalog of cancer driver mutations in protein-coding genes has greatly expanded in the past decade. However, non-coding cancer driver mutations are less well-characterized and only a handful of recurrent non-coding mutations, most notably TERT… read more here.
Keywords: pathway network; analysis; non coding; coding mutations ... See more keywords
SWAN pathway-network identification of common aneuploidy-based oncogenic drivers
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac200
Abstract: Abstract Haploinsufficiency drives Darwinian evolution. Siblings, while alike in many aspects, differ due to monoallelic differences inherited from each parent. In cancer, solid tumors exhibit aneuploid genetics resulting in hundreds to thousands of monoallelic gene-level… read more here.
Keywords: pathway network; network; network identification; identification common ... See more keywords
Construction of miRNA-regulated drug-pathway network to screen drug repurposing candidates for multiple sclerosis.
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000029107
Abstract: ABSTRACT Given the high disability rate of multiple sclerosis (MS), there is a need for safer and more effective therapeutic agents. Existing literature highlights the prominent roles of miRNA in MS pathophysiology. Nevertheless, there are… read more here.
Keywords: regulated drug; drug; mirna regulated; drug pathway ... See more keywords
Multi-View Subspace Clustering via Structured Multi-Pathway Network.
Sign Up to like & getrecommendations! Published in 2022 at "IEEE transactions on neural networks and learning systems"
DOI: 10.1109/tnnls.2022.3213374
Abstract: Recently, deep multi-view clustering (MVC) has attracted increasing attention in multi-view learning owing to its promising performance. However, most existing deep multi-view methods use single-pathway neural networks to extract features of each view, which cannot… read more here.
Keywords: pathway network; multi; multi view; multi pathway ... See more keywords
Pathway Network Analysis of Complex Diseases Based on Multiple Biological Networks
Sign Up to like & getrecommendations! Published in 2018 at "BioMed Research International"
DOI: 10.1155/2018/5670210
Abstract: Biological pathways play important roles in the development of complex diseases, such as cancers, which are multifactorial complex diseases that are usually caused by multiple disorders gene mutations or pathway. It has become one of… read more here.
Keywords: analysis complex; pathway network; network; complex diseases ... See more keywords
Multiomics-Based Signaling Pathway Network Alterations in Human Non-functional Pituitary Adenomas
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2019.00835
Abstract: Non-functional pituitary adenoma (NFPA) seriously affects hypothanamus-pituitary-target organ axis system, with a series of molecule alterations in the multiple levels of genome, transcriptome, proteome, and post-translational modifications, and those molecules mutually interact in a molecular-network… read more here.
Keywords: functional pituitary; pathway network; network; pathway ... See more keywords
Comprehensive analysis of potential cellular communication networks in advanced osteosarcoma using single-cell RNA sequencing data
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.1013737
Abstract: Osteosarcoma (OS) is a common bone cancer in children and adolescents, and metastasis and recurrence are the major causes of poor treatment outcomes. A better understanding of the tumor microenvironment is required to develop an… read more here.
Keywords: pathway network; cell; analysis; signaling pathway ... See more keywords
Pathway and network analysis of genes related to osteoporosis
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2019.10353
Abstract: As a common degenerative disease, osteoporosis (OS) is characterized by reduced bone mass and microarchitectural deterioration of bone tissue. Both genetic and environmental factors are involved in OS development. To date, ~300 genes have been… read more here.
Keywords: pathway network; network; genes related; network analysis ... See more keywords