Serotonergic Modulation of Sensory Representation in a Central Multisensory Circuit Is Pathway Specific
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.07.079
Abstract: SUMMARY Many studies have explored how neuromodulators affect synaptic function, yet little is known about how they modify computations at the microcircuit level. In the dorsal cochlear nucleus (DCN), a region that integrates auditory and… read more here.
Keywords: serotonergic modulation; multisensory; pathway specific; circuit ... See more keywords
Interplay between global and pathway-specific synaptic plasticity in CA1 pyramidal cells
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-17161-z
Abstract: Mechanisms underlying information storage have been depicted for global cell-wide and pathway-specific synaptic plasticity. Yet, little is known how these forms of plasticity interact to enhance synaptic competition and network stability. We examined synaptic interactions… read more here.
Keywords: pathway specific; ca1 pyramidal; specific synaptic; pathway ... See more keywords
Function of pathway specific regulators in the ACE1 and pyrichalasin H biosynthetic gene clusters
Sign Up to like & getrecommendations! Published in 2019 at "RSC Advances"
DOI: 10.1039/c9ra07028a
Abstract: Transcription factors from the biosynthesis of fungal metabolites were investigated by ectopic expression: pyiR from the pyrichalasin cluster enhanced titres of pyrichalasin H 1; but BC1 from the ACE1 cluster unexpectedly induced hinnulin A 4. read more here.
Keywords: ace1 pyrichalasin; pyrichalasin; pathway specific; function pathway ... See more keywords
Pathway-specific population attributable fractions
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Epidemiology"
DOI: 10.1093/ije/dyac079
Abstract: Abstract Introduction A population attributable fraction represents the relative change in disease prevalence that one might expect if a particular exposure was absent from the population. Often, one might be interested in what percentage of… read more here.
Keywords: pathway specific; disease; risk; population attributable ... See more keywords
Pathway-specific protein domains are predictive for human diseases
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1007052
Abstract: Protein domains are basic functional units of proteins. Many protein domains are pervasive among diverse biological processes, yet some are associated with specific pathways. Human complex diseases are generally viewed as pathway-level disorders. Therefore, we… read more here.
Keywords: protein; pathway specific; specific domains; protein domains ... See more keywords
Dissecting the Polygenic Basis of Primary Hypertension: Identification of Key Pathway-Specific Components
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.814502
Abstract: Introduction and Objectives Genome-wide association studies have identified a high number of genetic loci associated with hypertension suggesting the presence of an underlying polygenic architecture. In this study, we aimed to dissect the polygenic component… read more here.
Keywords: pathway specific; hypertension; specific components; prs ... See more keywords
Cross-Talking of Pathway-Specific Regulators in Glycopeptide Antibiotics (Teicoplanin and A40926) Production
Sign Up to like & getrecommendations! Published in 2023 at "Antibiotics"
DOI: 10.3390/antibiotics12040641
Abstract: Teicoplanin and A40926 (natural precursor of dalbavancin) are clinically relevant glycopeptide antibiotics (GPAs) produced by Actinoplanes teichomyceticus NRRL B-16726 and Nonomuraea gerenzanensis ATCC 39727. Their biosynthetic enzymes are coded within large biosynthetic gene clusters (BGCs),… read more here.
Keywords: pathway specific; glycopeptide antibiotics; teicoplanin a40926; gerenzanensis ... See more keywords
Pathway-specific dysregulation of striatal excitatory synapses by LRRK2 mutations
Sign Up to like & getrecommendations! Published in 2020 at "eLife"
DOI: 10.7554/elife.58997
Abstract: LRRK2 is a kinase expressed in striatal spiny projection neurons (SPNs), cells which lose dopaminergic input in Parkinson’s disease (PD). R1441C and G2019S are the most common pathogenic mutations of LRRK2. How these mutations alter… read more here.
Keywords: excitatory; specific dysregulation; pathway specific; lrrk2 mutations ... See more keywords
Pathway-specific effects of ADSL deficiency on neurodevelopment
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.70518
Abstract: Adenylosuccinate lyase (ADSL) functions in de novo purine synthesis (DNPS) and the purine nucleotide cycle. ADSL deficiency (ADSLD) causes numerous neurodevelopmental pathologies, including microcephaly and autism spectrum disorder. ADSLD patients have normal serum purine nucleotide… read more here.
Keywords: pathway specific; effects adsl; purine; adsl deficiency ... See more keywords