Novel [l,2,4]triazolo[3,4-a]isoquinoline chalcones as new chemotherapeutic agents: Block IAP tyrosine kinase domain and induce both intrinsic and extrinsic pathways of apoptosis
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DOI: 10.1007/s10637-020-00987-2
Abstract: Two novel chemotherapeutic chalcones were synthesized and their structures were confirmed by different spectral tools. Theoretical studies such as molecular modeling were done to detect the mechanism of action of these compounds. In vitro cytotoxicity… read more here.
Keywords: triazolo isoquinoline; lung carcinoma; pathways apoptosis; novel triazolo ... See more keywords