Characterization and optimization of two-chain folding pathways of insulin via native chain assembly
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DOI: 10.1038/s42004-018-0024-0
Abstract: Until recently the total synthesis of insulin, with its characteristic heterodimeric structure crosslinked by two interchain and one intrachain disulfide (SS) bridge, remained largely an unsolved challenge. By optimizing the synthesis and directed disulfide crosslinking… read more here.
Keywords: insulin; chain; folding pathways; pathways insulin ... See more keywords