A neuromuscular perspective of sarcopenia pathogenesis: deciphering the signaling pathways involved
Sign Up to like & getrecommendations! Published in 2022 at "GeroScience"
DOI: 10.1007/s11357-021-00510-2
Abstract: The escalation of life expectancy is accompanied by an increase in the prevalence of age-related conditions, such as sarcopenia. Sarcopenia, a muscle condition defined by low muscle strength, muscle quality or quantity, and physical performance,… read more here.
Keywords: sarcopenia pathogenesis; signaling pathways; muscle; pathways involved ... See more keywords
Identification of transcriptomic signatures and crucial pathways involved in non-alcoholic steatohepatitis
Sign Up to like & getrecommendations! Published in 2021 at "Endocrine"
DOI: 10.1007/s12020-021-02716-y
Abstract: Our study aimed to uncover the crucial genes and functional pathways involved in the development of non-alcoholic steatohepatitis (NASH). Liver transcriptome datasets were integrated with Robust rank aggregation (RRA) method, and transcriptomic signatures for NASH… read more here.
Keywords: fibrosis; non alcoholic; alcoholic steatohepatitis; transcriptomic signatures ... See more keywords
Dissecting the signaling pathways involved in the function of sperm flagellum.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in cell biology"
DOI: 10.1016/j.ceb.2020.01.015
Abstract: The mammalian flagellum is a specific type of motile cilium required for sperm motility and male fertility. Effective flagellar movement is dependent on axonemal function, which in turn relies on proper ion homeostasis within the… read more here.
Keywords: signaling pathways; ion; pathways involved; involved function ... See more keywords
Signaling pathways involved in cell cycle arrest during the DNA breaks.
Sign Up to like & getrecommendations! Published in 2021 at "DNA repair"
DOI: 10.1016/j.dnarep.2021.103047
Abstract: Our genome bears tens of thousands of harms and devastations per day; In this regard, numerous sophisticated and complicated mechanisms are embedded by our cells in furtherance of remitting an unchanged and stable genome to… read more here.
Keywords: signaling pathways; dna; cell cycle; pathways involved ... See more keywords
Molecular pathways involved in lymphedema: hydroxytyrosol as a candidate natural compound for treating the symptoms caused by lymph accumulation.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of biotechnology"
DOI: 10.1016/j.jbiotec.2019.11.017
Abstract: Lymphedema is a chronic accumulation of interstitial fluid due to inefficient lymph drainage. Major causes of lymphedema are malformations of lymphatic vessels, trauma, toxic damage and surgery. The swelling typically affects the limbs. Lymphedema may… read more here.
Keywords: accumulation; hydroxytyrosol; compound; pathways involved ... See more keywords
Pathways involved in the human vascular Tetrabromobisphenol A response: calcium and potassium channels and nitric oxide donors.
Sign Up to like & getrecommendations! Published in 2022 at "Toxicology"
DOI: 10.1016/j.tox.2022.153158
Abstract: Tetrabromobisphenol A (TBBPA) is a flame retardant that can contaminate the environment and human being, acting as an endocrine disruptor. Several studies propose a correlation between TBBPA exposure and adverse health outcomes, however, at vascular… read more here.
Keywords: tbbpa; pathways involved; exposure; tetrabromobisphenol ... See more keywords
Depigmenting topical therapy based on a synergistic combination of compounds targeting the key pathways involved in melasma pathophysiology
Sign Up to like & getrecommendations! Published in 2023 at "Experimental Dermatology"
DOI: 10.1111/exd.14752
Abstract: Melasma has a complex pathophysiology with different cell types and signalling pathways involved. Paracrine factors secreted by keratinocytes, fibroblasts and endothelial cells act on melanocytes and stimulate melanogenesis. These paracrine factors are involved in the… read more here.
Keywords: combination compounds; involved melasma; pathophysiology; combination ... See more keywords
Genome‐wide transcriptomic changes reveal the genetic pathways involved in insect migration
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Ecology"
DOI: 10.1111/mec.16588
Abstract: Insects are capable of extraordinary feats of long‐distance movement that have profound impacts on the function of terrestrial ecosystems. The ability to undertake these movements arose multiple times through the evolution of a suite of… read more here.
Keywords: wide transcriptomic; genetic pathways; genome wide; pathways involved ... See more keywords
Signaling Pathways Involved in the Regulation of mRNA Translation
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Cellular Biology"
DOI: 10.1128/mcb.00070-18
Abstract: ABSTRACT Translation is a key step in the regulation of gene expression and one of the most energy-consuming processes in the cell. In response to various stimuli, multiple signaling pathways converge on the translational machinery… read more here.
Keywords: signaling pathways; regulation mrna; mrna translation; translation ... See more keywords
Analysis of Potential Genes and Pathways Involved in the Pathogenesis of Acne by Bioinformatics
Sign Up to like & getrecommendations! Published in 2019 at "BioMed Research International"
DOI: 10.1155/2019/3739086
Abstract: Acne is the eighth most frequent disease worldwide. Inflammatory response runs through all stages of acne. It is complicated and is involved in innate and adaptive immunity. This study aimed to explore the candidate genes… read more here.
Keywords: degs; analysis; pathogenesis; pathways involved ... See more keywords
Prediction of novel target genes and pathways involved in bevacizumab-resistant colorectal cancer
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0189582
Abstract: Bevacizumab combined with cytotoxic chemotherapy is the backbone of metastatic colorectal cancer (mCRC) therapy; however, its treatment efficacy is hampered by therapeutic resistance. Therefore, understanding the mechanisms underlying bevacizumab resistance is crucial to increasing the… read more here.
Keywords: involved bevacizumab; genes pathways; colorectal cancer; bevacizumab resistant ... See more keywords