Preclinical patient-derived modelling of castration-resistant prostate cancer facilitates individualized assessment of homologous recombination repair deficient disease.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular oncology"
DOI: 10.1002/1878-0261.13382
Abstract: The use of mutation analysis of homologous recombination repair (HRR) genes to estimate PARP‐inhibition response may miss a larger proportion of responding patients. Here, we provide preclinical models for castration‐resistant prostate cancer (CRPC) that can… read more here.
Keywords: prostate cancer; castration resistant; patient derived;
Patient‐derived in vitro skin models for investigation of small fiber pathology
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.50871
Abstract: To establish individually expandable primary fibroblast and keratinocyte cultures from 3‐mm skin punch biopsies for patient‐derived in vitro skin models to investigate of small fiber pathology. read more here.
Keywords: derived vitro; skin models; vitro skin; small fiber ... See more keywords
An Engineered Patient‐Derived Tumor Organoid Model That Can Be Disassembled to Study Cellular Responses in a Graded 3D Microenvironment
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202105349
Abstract: Patient‐derived organoids (PDOs) are emerging as powerful models to capture the genetic heterogeneity of human tumors. However, the self‐assembling nature of PDOs limits their use in studies of the impact of microenvironmental heterogeneity on tumor… read more here.
Keywords: tumor; response; model; patient derived ... See more keywords
Patient-Derived Prostate Cancer Explants: A Clinically Relevant Model to Assess siRNA-Based Nanomedicines.
Sign Up to like & getrecommendations! Published in 2020 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202001594
Abstract: Over the last thirty years, research in nanomedicine has widely been focused on applications in cancer therapeutics. However, despite the plethora of reported nanoscale drug delivery systems that can successfully eradicate solid tumor xenografts in… read more here.
Keywords: relevant model; prostate cancer; model; clinically relevant ... See more keywords
Quenching Epigenetic Drug Resistance Using Anti-hypoxic Microparticles in Glioblastoma Patient-derived Chips.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202102226
Abstract: Glioblastoma is one of the most intractable tumor types due to the progressive drug resistance upon tumor mass expansion. Incremental hypoxia inside the growing tumor mass drives epigenetic drug resistance by activating non-genetic repair of… read more here.
Keywords: drug; drug resistance; chip; epigenetic drug ... See more keywords
Bioprinting of Patient-Derived Organoids for Predicting Cancer Therapy Responses.
Sign Up to like & getrecommendations! Published in 2022 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202102784
Abstract: Cancer models. This article is protected by copyright. All rights reserved. read more here.
Keywords: cancer; predicting cancer; organoids predicting; derived organoids ... See more keywords
A 3D Perfusable Platform for In Vitro Culture of Patient Derived Xenografts
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202201434
Abstract: Many advanced cancer models, such as patient‐derived xenografts (PDXs), offer significant benefits in their preservation of the native tumor's heterogeneity and susceptibility to treatments, but face significant barriers to use in their reliance on a… read more here.
Keywords: derived xenografts; vitro culture; perfusable platform; platform vitro ... See more keywords
Organic Small Molecule Contrast Agent for Targeted Photoacoustic Imaging of Patient‐Derived Brain Tumors
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202201640
Abstract: Traditional glioblastoma (GBM) cell lines do not maintain the heterogeneity of the original tumor, cell interactions, and therapy response, thus limiting their investigation in GBM theranostics. Herein, a kind of GBM tumor‐targeting nanoparticles (NPs) TCFNP@iRGD… read more here.
Keywords: contrast agent; patient derived; gbm;
Engineered Matrices Enable the Culture of Human Patient‐Derived Intestinal Organoids
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Science"
DOI: 10.1002/advs.202004705
Abstract: Abstract Human intestinal organoids from primary human tissues have the potential to revolutionize personalized medicine and preclinical gastrointestinal disease models. A tunable, fully defined, designer matrix, termed hyaluronan elastin‐like protein (HELP) is reported, which enables… read more here.
Keywords: help materials; engineered matrices; intestinal organoids; help ... See more keywords
Rapid Profiling of Tumor‐Immune Interaction Using Acoustically Assembled Patient‐Derived Cell Clusters
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DOI: 10.1002/advs.202201478
Abstract: Tumor microenvironment crosstalk, in particular interactions between cancer cells, T cells, and myeloid‐derived suppressor cells (MDSCs), mediates tumor initiation, progression, and response to treatment. However, current patient‐derived models such as tumor organoids and 2D cultures… read more here.
Keywords: cell; acoustically assembled; tumor immune; patient derived ... See more keywords
Colorectal Cancer Patient‐Derived 2D and 3D Models Efficiently Recapitulate Inter‐ and Intratumoral Heterogeneity
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202201539
Abstract: Pre‐existing drug resistance and tumorigenicity of cancer cells are highly correlated with therapeutic failure and tumor growth. However, current cancer models are limited in their application to the study of intratumor functional heterogeneity in personalized… read more here.
Keywords: cancer; pre existing; existing drug; colorectal cancer ... See more keywords