Genetic-based patient stratification in Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-60707-1
Abstract: Alzheimer's disease (AD) shows a high pathological and symptomatological heterogeneity. To study this heterogeneity, we have developed a patient stratification technique based on one of the most significant risk factors for the development of AD:… read more here.
Keywords: alzheimer disease; disease; genetics; disease genetic ... See more keywords
PATH-10. UTILIZATION OF TUMOR-DERIVED EXTRACELLULAR VESICLES FOR PATIENT STRATIFICATION AND BIOMARKER DISCOVERY
Sign Up to like & getrecommendations! Published in 2024 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noae165.0709
Abstract: Liquid biopsy is poised to play an increasingly important role in clinical decision making by enabling earlier cancer detection, diagnosis, patient stratification, and treatment monitoring. Most approaches rely on detection of cell-free circulating tumor DNA… read more here.
Keywords: oncology; extracellular vesicles; cancer; patient stratification ... See more keywords
Biomarker discovery studies for patient stratification using machine learning analysis of omics data: a scoping review
Sign Up to like & getrecommendations! Published in 2021 at "BMJ Open"
DOI: 10.1136/bmjopen-2021-053674
Abstract: Objective To review biomarker discovery studies using omics data for patient stratification which led to clinically validated FDA-cleared tests or laboratory developed tests, in order to identify common characteristics and derive recommendations for future biomarker… read more here.
Keywords: review; biomarker; machine learning; patient stratification ... See more keywords
Abstract 7647: Identification of transcriptional plasticity biomarkers for patient stratification
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-7647
Abstract: Biomarker signatures associated with disease progression are important tools for the management of patient care. However, such signatures are frequently indication-specific, which limits their utility to stratify broader populations. Transcriptional plasticity, the ability of a… read more here.
Keywords: cell lines; response; plasticity; patient stratification ... See more keywords
Abstract 7203: Systematic pan-cancer functional patient stratification to advance therapy personalization in rare solid tumors
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-7203
Abstract: To date, comprehensive omics sequencing has greatly advanced cancer therapies and precision oncology. However, rare cancers remain challenging due to unique genetic profiles and low prevalence, limiting molecular mechanism-oriented treatment strategies. Comprehensive precision oncology programs… read more here.
Keywords: oncology; cancer; drug; patient stratification ... See more keywords
Highly Comprehensive Genomic Testing for CLL: WGS, One Key to CLL Patient Stratification
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-115935
Abstract: Background Chronic Lymphocytic Leukemia (CLL) is characterised by a highly heterogeneous natural history and treatment response. Indeed, 50% of immunoglobulin heavy chain variable region (IgHV) hypermutated patients have an excellent progression free survival (PFS) after… read more here.
Keywords: patient stratification; cll; research funding;
ClustAll: An R package for patient stratification in complex diseases
Sign Up to like & getrecommendations! Published in 2024 at "PLOS Computational Biology"
DOI: 10.1371/journal.pcbi.1012656
Abstract: In the era of precision medicine, it is necessary to understand heterogeneity among patients with complex diseases to improve personalized prevention and management strategies. Here, we introduce ClustAll, a Bioconductor package designed for unsupervised patient… read more here.
Keywords: stratification; patient stratification; medicine; complex diseases ... See more keywords
Consideration of clinicopathologic features improves patient stratification for multimodal treatment of gastric cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.18607
Abstract: Preoperative staging of gastric cancer with computed tomography alone exhibits poor diagnostic accuracy, which may lead to improper treatment decisions. We developed novel patient stratification criteria to select appropriate treatments for gastric cancer patients based… read more here.
Keywords: gastric cancer; treatment; patient stratification; cancer ... See more keywords
Multi-Omic Biomarkers for Patient Stratification in Sjogren’s Syndrome—A Review of the Literature
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10081773
Abstract: Sjögren’s syndrome (SS) is a heterogeneous autoimmune rheumatic disease (ARD) characterised by dryness due to the chronic lymphocytic infiltration of the exocrine glands. Patients can also present other extra glandular manifestations, such as arthritis, anaemia… read more here.
Keywords: multi omic; review; biomarkers patient; omic biomarkers ... See more keywords
Association of Peripheral Inflammatory Biomarkers and Growth Factors Levels with Sex, Therapy and Other Clinical Factors in Schizophrenia and Patient Stratification Based on These Data
Sign Up to like & getrecommendations! Published in 2023 at "Brain Sciences"
DOI: 10.3390/brainsci13050836
Abstract: Multiple lines of evidence are known to confirm the pro-inflammatory state of some patients with schizophrenia and the involvement of inflammatory mechanisms in the pathogenesis of psychosis. The concentration of peripheral biomarkers is associated with… read more here.
Keywords: growth; therapy; inflammatory; sex ... See more keywords
Circulating miRNAs as Potential Biomarkers for Patient Stratification in Bipolar Disorder: A Combined Review and Data Mining Approach
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13061038
Abstract: Bipolar disorder is a debilitating psychiatric condition that is shaped in a concerted interplay between hereditary and triggering risk factors. Profound depression and mania define the disorder, but high clinical heterogeneity among patients complicates diagnosis… read more here.
Keywords: mining approach; bipolar disorder; stratification bipolar; disorder ... See more keywords