Biomarker discovery studies for patient stratification using machine learning analysis of omics data: a scoping review
Sign Up to like & getrecommendations! Published in 2021 at "BMJ Open"
DOI: 10.1136/bmjopen-2021-053674
Abstract: Objective To review biomarker discovery studies using omics data for patient stratification which led to clinically validated FDA-cleared tests or laboratory developed tests, in order to identify common characteristics and derive recommendations for future biomarker… read more here.
Keywords: review; biomarker; machine learning; patient stratification ... See more keywords
Highly Comprehensive Genomic Testing for CLL: WGS, One Key to CLL Patient Stratification
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-115935
Abstract: Background Chronic Lymphocytic Leukemia (CLL) is characterised by a highly heterogeneous natural history and treatment response. Indeed, 50% of immunoglobulin heavy chain variable region (IgHV) hypermutated patients have an excellent progression free survival (PFS) after… read more here.
Keywords: patient stratification; cll; research funding;
Consideration of clinicopathologic features improves patient stratification for multimodal treatment of gastric cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.18607
Abstract: Preoperative staging of gastric cancer with computed tomography alone exhibits poor diagnostic accuracy, which may lead to improper treatment decisions. We developed novel patient stratification criteria to select appropriate treatments for gastric cancer patients based… read more here.
Keywords: gastric cancer; treatment; patient stratification; cancer ... See more keywords
Multi-Omic Biomarkers for Patient Stratification in Sjogren’s Syndrome—A Review of the Literature
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10081773
Abstract: Sjögren’s syndrome (SS) is a heterogeneous autoimmune rheumatic disease (ARD) characterised by dryness due to the chronic lymphocytic infiltration of the exocrine glands. Patients can also present other extra glandular manifestations, such as arthritis, anaemia… read more here.
Keywords: multi omic; review; biomarkers patient; omic biomarkers ... See more keywords
Association of Peripheral Inflammatory Biomarkers and Growth Factors Levels with Sex, Therapy and Other Clinical Factors in Schizophrenia and Patient Stratification Based on These Data
Sign Up to like & getrecommendations! Published in 2023 at "Brain Sciences"
DOI: 10.3390/brainsci13050836
Abstract: Multiple lines of evidence are known to confirm the pro-inflammatory state of some patients with schizophrenia and the involvement of inflammatory mechanisms in the pathogenesis of psychosis. The concentration of peripheral biomarkers is associated with… read more here.
Keywords: growth; therapy; inflammatory; sex ... See more keywords
Circulating miRNAs as Potential Biomarkers for Patient Stratification in Bipolar Disorder: A Combined Review and Data Mining Approach
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13061038
Abstract: Bipolar disorder is a debilitating psychiatric condition that is shaped in a concerted interplay between hereditary and triggering risk factors. Profound depression and mania define the disorder, but high clinical heterogeneity among patients complicates diagnosis… read more here.
Keywords: mining approach; bipolar disorder; stratification bipolar; disorder ... See more keywords
COVID-19 Biomarkers at the Crossroad between Patient Stratification and Targeted Therapy: The Role of Validated and Proposed Parameters
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24087099
Abstract: Clinical knowledge about SARS-CoV-2 infection mechanisms and COVID-19 pathophysiology have enormously increased during the pandemic. Nevertheless, because of the great heterogeneity of disease manifestations, a precise patient stratification at admission is still difficult, thus rendering… read more here.
Keywords: biomarkers crossroad; stratification; routine clinical; clinical practice ... See more keywords
Patient Stratification in Sepsis: Using Metabolomics to Detect Clinical Phenotypes, Sub-Phenotypes and Therapeutic Response
Sign Up to like & getrecommendations! Published in 2022 at "Metabolites"
DOI: 10.3390/metabo12050376
Abstract: Infections are common and need minimal treatment; however, occasionally, due to inappropriate immune response, they can develop into a life-threatening condition known as sepsis. Sepsis is a global concern with high morbidity and mortality. There… read more here.
Keywords: sepsis; stratification sepsis; sepsis using; response ... See more keywords
Patient stratification using point of care biomarkers in dry eye disease
Sign Up to like & getrecommendations! Published in 2023 at "Indian Journal of Ophthalmology"
DOI: 10.4103/ijo.ijo_3363_22
Abstract: With changes in lifestyle, such as the increasing use of digital screens and rising demand for refractive surgery, dry eye disease has become increasingly prevalent in recent times. While we are equipped with a number… read more here.
Keywords: dry eye; eye; eye disease; stratification using ... See more keywords