Symptom-based network classification identifies distinct clinical subgroups of liver diseases with common molecular pathways
Sign Up to like & getrecommendations! Published in 2019 at "Computer methods and programs in biomedicine"
DOI: 10.1016/j.cmpb.2018.02.014
Abstract: BACKGROUND AND OBJECTIVE Liver disease is a multifactorial complex disease with high global prevalence and poor long-term clinical efficacy and liver disease patients with different comorbidities often incorporate multiple phenotypes in the clinic. Thus, there… read more here.
Keywords: classification; patient subgroups; network; liver diseases ... See more keywords
A systematic review and meta-analysis of PD-1/PD-L1 inhibitors in specific patient subgroups with advanced gastro-oesophageal junction and gastric adenocarcinoma.
Sign Up to like & getrecommendations! Published in 2020 at "Critical reviews in oncology/hematology"
DOI: 10.1016/j.critrevonc.2020.103173
Abstract: BACKGROUND immune checkpoint inhibitors(ICIs) have shown contradictory results in patients with advanced gastro-oesophageal junction/gastric cancer(GOJ/GC). AIM to identify specific patient subgroups that would derive survival benefit from ICIs. METHODS a subgroup meta-analysis of randomised clinical… read more here.
Keywords: patient subgroups; advanced gastro; junction gastric; specific patient ... See more keywords
On how to not misuse hierarchical clustering on principal components to define clinically meaningful patient subgroups. Response to: ‘On using machine learning algorithms to define clinical meaningful patient subgroups’ by Pinal-Fernandez and Mammen
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-215868
Abstract: We thank Pinal-Fernandez and Mammen for their interesting methodological comment on our work in which we used hierarchical clustering on principal components to define clinically meaningful subgroups of patients with anti-Ku antibodies.1 2 We fully… read more here.
Keywords: clustering principal; patient subgroups; meaningful patient; hierarchical clustering ... See more keywords
Response to: ‘On using machine learning algorithms to define clinically meaningful patient subgroups’ by Pinal-Fernandez and Mammen
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-216007
Abstract: We have read with interest the comment from Pinal-Fernandez and Mammen in which they question the statistical clustering methods based on unsupervised learning analyses to define clinically meaningful patient subgroups.1 Pinal-Fernandez and Mammen base their… read more here.
Keywords: patient subgroups; meaningful patient; define clinically; pinal fernandez ... See more keywords
Bridging across patient subgroups in phase I oncology trials that incorporate animal data
Sign Up to like & getrecommendations! Published in 2021 at "Statistical Methods in Medical Research"
DOI: 10.1177/0962280220986580
Abstract: In this paper, we develop a general Bayesian hierarchical model for bridging across patient subgroups in phase I oncology trials, for which preliminary information about the dose–toxicity relationship can be drawn from animal studies. Parameters… read more here.
Keywords: patient subgroups; phase oncology; bridging across; across patient ... See more keywords
Identification of Sjögren’s syndrome patient subgroups by clustering of labial salivary gland DNA methylation profiles
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0281891
Abstract: Heterogeneity in Sjögren’s syndrome (SS), increasingly called Sjögren’s disease, suggests the presence of disease subtypes, which poses a major challenge for the diagnosis, management, and treatment of this autoimmune disorder. Previous work distinguished patient subgroups… read more here.
Keywords: methylation; gren syndrome; dna methylation; labial salivary ... See more keywords
Aberrant signaling of immune cells in Sjögren’s syndrome patient subgroups upon interferon stimulation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.854183
Abstract: Background Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease, characterized by mononuclear cell infiltrates in the salivary and lacrimal glands, leading to glandular atrophy and dryness. Patient heterogeneity and lack of knowledge regarding its… read more here.
Keywords: cell; pstat1 y701; gren syndrome; pss patients ... See more keywords
Conformation-stabilizing ELISA and cell-based assays reveal patient subgroups targeting three different epitopes of AGO1 antibodies
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.972161
Abstract: Autoantibodies (Abs) are biomarkers for many disease conditions and are increasingly used to facilitate diagnosis and treatment decisions. To guarantee high sensitivity and specificity, the choice of their detection method is crucial. Via cell-based assays,… read more here.
Keywords: cell based; stabilizing elisa; conformation; ago1 abs ... See more keywords
Re-Identification of Patient Subgroups in Uveal Melanoma
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.731548
Abstract: Uveal melanoma (UM) is a comparatively rare cancer but requires serious consideration since patients with developing metastatic UM survive only for about 6–12 months. Fortunately, increasingly large multi-omics databases allow us to further understand cancer… read more here.
Keywords: patient subgroups; specific genes; subgroups uveal; uveal melanoma ... See more keywords