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   Articles with "patient variability" as a keyword



Exploring the Association Between Intra‐Patient Variability in Trough Concentration of Pazopanib and Clinical Outcomes in Renal Cell Carcinoma and Soft Tissue Sarcoma Patients

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recommendations! Published in 2025 at "Clinical Pharmacology and Therapeutics"

DOI: 10.1002/cpt.3728

Abstract: Pazopanib is an oral tyrosine kinase inhibitor used in patients with either metastatic renal cell carcinoma or soft tissue sarcoma. Pazopanib has a high interindividual variability in pharmacokinetics and pharmacodynamics and a well‐established exposure–response relationship.… read more here.

Keywords: patient variability; pazopanib; variability; intra patient ... See more keywords

Addressing patient to patient variability for autologous CAR T therapies.

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recommendations! Published in 2020 at "Journal of pharmaceutical sciences"

DOI: 10.1016/j.xphs.2020.12.015

Abstract: Chimeric Antigen Receptor (CAR) T cell therapy clinical trials have had unprecedented success in the endeavors to cure cancer patients, particularly those having hematological cancers. As researchers learn more about the ways to make CAR… read more here.

Keywords: addressing patient; patient variability; car cells; cancer patients ... See more keywords

P966 The intra-patient variability of adalimumab clearance during an intensive sampling study of Crohn’s disease patients receiving maintenance therapy

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recommendations! Published in 2024 at "Journal of Crohn's and Colitis"

DOI: 10.1093/ecco-jcc/jjad212.1096

Abstract: Lower adalimumab (ADA) clearance (CL) is associated with improved outcomes in Crohn’s disease (CD) and may be a superior pharmacokinetic (PK) measure than ADA concentrations. We compared intra-patient variability in ADA CL and concentrations within… read more here.

Keywords: patient variability; intra patient; day; ada concentrations ... See more keywords

Tacrolimus Intra-Patient Variability, Time in Therapeutic Range, and Risk of De Novo Donor-Specific Antibodies.

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recommendations! Published in 2019 at "Transplantation"

DOI: 10.1097/tp.0000000000002913

Abstract: BACKGROUND Tacrolimus (TAC) is the most important agent for maintenance immunosuppression and prevention of immunologic injury to the renal allograft, yet there remains no consensus on how best to monitor drug therapy. Both high TAC… read more here.

Keywords: patient variability; risk; variability; tac ... See more keywords

Intra‐patient variability in tacrolimus exposure in pediatric liver transplant recipients: Evolution, risk factors, and impact on patient outcomes

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recommendations! Published in 2019 at "Pediatric Transplantation"

DOI: 10.1111/petr.13388

Abstract: This study aims to investigate the evolution and factors associated with TAC IPV and its impact on patient outcomes in pediatric LT recipients. read more here.

Keywords: evolution; impact patient; patient outcomes; variability tacrolimus ... See more keywords

Spontaneous variability of pre-dialysis concentrations of uremic toxins over time in stable hemodialysis patients

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recommendations! Published in 2017 at "PLoS ONE"

DOI: 10.1371/journal.pone.0186010

Abstract: Background and aim Numerous outcome studies and interventional trials in hemodialysis (HD) patients are based on uremic toxin concentrations determined at one single or a limited number of time points. The reliability of these studies… read more here.

Keywords: uremic toxins; time; variability; concentrations uremic ... See more keywords

Combined impact of the inter and intra-patient variability of tacrolimus blood level on allograft outcomes in kidney transplantation

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recommendations! Published in 2022 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2022.1037566

Abstract: Introduction Tacrolimus (TAC) has been widely used as an immunosuppressant after kidney transplantation (KT); however, the combined effects of intra-patient variability (IPV) and inter-patient variability of TAC-trough level (C0) in blood remain controversial. This study… read more here.

Keywords: allograft outcomes; high ipv; inter; ipv ... See more keywords

Exploring inter-ethnic and inter-patient variability and optimal dosing of osimertinib: a physiologically based pharmacokinetic modeling approach

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recommendations! Published in 2024 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2024.1363259

Abstract: Purpose: This study aimed to develop and validate a physiologically based pharmacokinetic (PBPK) model for osimertinib (OSI) to predict plasma trough concentration (Ctrough) and pulmonary EGFRm+ (T790M and L858R mutants) inhibition in Caucasian, Japanese, and… read more here.

Keywords: ethnic inter; patient variability; inter; optimal dosing ... See more keywords