Epigenetic therapy of myelodysplastic syndromes connects to cellular differentiation independently of endogenous retroelement derepression
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DOI: 10.1186/s13073-019-0707-x
Abstract: BackgroundMyelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML) are characterised by abnormal epigenetic repression and differentiation of bone marrow haematopoietic stem cells (HSCs). Drugs that reverse epigenetic repression, such as 5-azacytidine (5-AZA), induce haematological improvement… read more here.
Keywords: treatment; cmml patients; patients aza; differentiation ... See more keywords