Association of Genetic Variants With Outcomes in Patients With Nonischemic Dilated Cardiomyopathy.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2021.08.039
Abstract: BACKGROUND The clinical relevance of genetic variants in nonischemic dilated cardiomyopathy (DCM) is unsettled. OBJECTIVES The study sought to assess the prognostic impact of disease-causing genetic variants in DCM. METHODS Baseline and longitudinal clinical data… read more here.
Keywords: genotype negative; genetic variants; patients genotype; genotype positive ... See more keywords
P771Metoprolol succinate efficacy in patients with chronic heart failure on the background of obesity: genetic aspects of individual sensitivity and tolerability
Sign Up to like & getrecommendations! Published in 2019 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehz747.0371
Abstract: The cornerstone of modern cardiology is the problem of comorbidity, the combination of chronic heart failure (CHF) with obesity as well. Efficacy of treatment with beta-blockers in different patients varies significantly, partly depending on genotypically… read more here.
Keywords: heart; treatment; patients genotype; efficacy ... See more keywords
Real-life prevalence of resistance-associated variants against non-structural protein 5A inhibitors and efficiency of Daclatasvir + Asunaprevir therapy in Korean patients with genotype 1b hepatitis C
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DOI: 10.1186/s12985-017-0826-1
Abstract: BackgroundDirect-acting antivirals (DAAs) for chronic hepatitis C (CHC) treatment are tolerable and highly effective in a shorter period of time than before. However, resistance-associated variants (RAVs) can affect the efficacy of DAAs. The aim of… read more here.
Keywords: hepatitis; treatment; patients genotype; associated variants ... See more keywords
Correlation study of venous thromboembolism with SAA, IL-1, and TNF-a levels and gene polymorphisms in Chinese population.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of thoracic disease"
DOI: 10.21037/jtd.2019.11.26
Abstract: Background The relationship between inflammation and venous thromboembolism (VTE) has not been fully elucidated. Methods Based on our previous studies, we detected the plasma levels of serum amyloid A protein (SAA), interleukin-1 (IL-1), and tumor… read more here.
Keywords: vte; saa; gene polymorphisms; patients genotype ... See more keywords
Differences in Short QT Syndrome Subtypes: A Systematic Literature Review and Pooled Analysis
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DOI: 10.3389/fgene.2019.01312
Abstract: Background Short QT syndrome (SQTS) is a rare syndrome and affects different types of genes. However, data on differences of clinical profile and outcome of different SQTS types are sparse. Methods We conducted a pooled… read more here.
Keywords: genotype negative; sqts; patients genotype; versus ... See more keywords
HCV Genotype-3h, a Difficult-to-Diagnose Sub-Genotype in the DAA Era
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DOI: 10.3851/imp3228
Abstract: Background No data are available on the clinical presentation and virological pattern in the case of failure of interferon (IFN)-free regimens in patients with genotype-3h. In this paper authors identified the virological and clinical characteristics… read more here.
Keywords: daa; genotype; hcv genotype; patients genotype ... See more keywords
Association between effectiveness of tuberculosis treatment and cytochrome P-4502E1 polymorphism of the patients
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DOI: 10.4103/ijmy.ijmy_168_17
Abstract: Context: The risk of antituberculosis (TB) drug-induced liver injury could be determined by patients' genotype polymorphism of the xenobiotic-metabolizing enzymes. To find the meaning of cytochrome P-4502E1 (CYP2E1) polymorphism in TB patients. Corresponding of CYP2E1… read more here.
Keywords: polymorphism patients; treatment; patients genotype; cytochrome 4502e1 ... See more keywords
Genetic polymorphism of CYP3A4 is associated with poor response to ifosfamide treatment in children with solid embryonic tumors
Sign Up to like & getrecommendations! Published in 2019 at "Archives of Medical Science"
DOI: 10.5114/aoms.2019.86648
Abstract: The CYP450 complex participates in the metabolism of ifosfamide, an antineoplastic drug used to treat solid tumors. genes contain several single nucleotide polymorphisms (SNPs) that confer different activity towards the enzyme. The aim of our… read more here.
Keywords: response; median mol; q25 q75; patients genotype ... See more keywords