Long-term cardiovascular safety of febuxostat compared with allopurinol in patients with gout (FAST): a multicentre, prospective, randomised, open-label, non-inferiority trial
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DOI: 10.1016/s0140-6736(20)32234-0
Abstract: BACKGROUND Febuxostat and allopurinol are urate-lowering therapies used to treat patients with gout. Following concerns about the cardiovascular safety of febuxostat, the European Medicines Agency recommended a post-licensing study assessing the cardiovascular safety of febuxostat… read more here.
Keywords: allopurinol; patients gout; non; febuxostat ... See more keywords
Effect of fenofibrate on uric acid level in patients with gout
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DOI: 10.1038/s41598-018-35175-z
Abstract: Gout is a chronic disease associated with deposition of monosodium urate crystals and accompanied by diabetes, hypertension, and dyslipidemia. Hypertriglyceridemia is common among patients with gout, and fenofibrate is usually used to reduce triglyceride levels.… read more here.
Keywords: uric acid; xanthine oxidase; effect; fenofibrate ... See more keywords
Evaluation of healthcare costs and utilization for patients with gout: a population-based matched cohort study
Sign Up to like & getrecommendations! Published in 2018 at "Current Medical Research and Opinion"
DOI: 10.1080/03007995.2017.1417826
Abstract: Abstract Objectives: To better understand the economic burden of gout patients in Taiwan, a nationwide retrospective study was conducted to compare the healthcare costs and utilization between gout and gout-free patients. Methods: The Longitudinal Health… read more here.
Keywords: study; healthcare costs; costs utilization; gout ... See more keywords
Increased Metallothionein-1 Associated with Gout Activity and Tophi
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DOI: 10.1080/08820139.2023.2173078
Abstract: ABSTRACT Background and aims Gout is a chronic self-limiting inflammatory arthritis. An increase in metallothionein-1 (MT-1) has been reported in rheumatoid arthritis and osteoarthritis, and it attenuates inflammation and the pathology of diseases. This study… read more here.
Keywords: gout; disease activity; patients gout; activity ... See more keywords
Model Informed Development of SIM0295 in Patients with Gout and Hyperuricemia and Healthy Volunteers Using a Population Pharmacokinetics/ Pharmacodynamics Approach.
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DOI: 10.1080/13543784.2023.2212153
Abstract: BACKGROUND SIM0295, a novel inhibitor of human uric acid transporter 1 (hURAT1), is used to treat patients with gout and hyperuricemia. This study aimed to develop population pharmacokinetics and pharmacodynamics (popPK/PD) models of SIM0295 and… read more here.
Keywords: gout hyperuricemia; development; patients gout; population pharmacokinetics ... See more keywords
Temporal evolution of urate crystal deposition over articular cartilage after successful urate-lowering therapy in patients with gout: An ultrasonographic perspective
Sign Up to like & getrecommendations! Published in 2017 at "Modern Rheumatology"
DOI: 10.1080/14397595.2016.1214229
Abstract: Abstract Objective: To detect evolution of ultrasonographic signs of deposition of monosodium urate crystals (MSUC) in gouty joints by serial ultrasonography after initiation of urate-lowering therapy (ULT). Methods: Adult gout patients were examined by serial… read more here.
Keywords: dcs; lowering therapy; deposition; urate lowering ... See more keywords
Achievement of the target serum urate level among patients with gout treated with allopurinol or febuxostat in an arthritis clinic in the Philippines
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DOI: 10.1080/14397595.2020.1800557
Abstract: Abstract Objective Gout is an important cause of disability among Filipinos, despite measures for effective management. This study aims to determine attainment of target serum uric acid level (SUA ≤ 6 mg/dl) among patients with gout… read more here.
Keywords: among patients; value; level; target ... See more keywords
Trends in risk factor control in patients with gout: data from the National Health and Nutrition Examination Survey, 2007-2018.
Sign Up to like & getrecommendations! Published in 2022 at "Rheumatology"
DOI: 10.1093/rheumatology/keac254
Abstract: OBJECTIVES To explore trends in risk factor control (hypertension, diabetes mellitus, hyperlipidemia) in patients with gout and medication use among those whose risk factor control targets were not achieved. METHODS We used the data from… read more here.
Keywords: factor control; control; trends risk; patients gout ... See more keywords
Clinical characteristics and risk factors of ulceration over tophi in patients with gout
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DOI: 10.1111/1756-185x.13581
Abstract: To describe clinical characteristics of ulceration over tophi in patients with gout and determine risk factors associated with ulceration. read more here.
Keywords: ulceration tophi; clinical characteristics; risk factors; patients gout ... See more keywords
Urate‐lowering therapy for patients with gout on hemodialysis
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DOI: 10.1111/1756-185x.14334
Abstract: Gout is the most common form of inflammatory arthritis and is caused by deposition of monosodium urate crystals resulting from a high burden of uric acid (UA). High UA burden also has been associated with… read more here.
Keywords: therapy patients; patients gout; gout hemodialysis; lowering therapy ... See more keywords
Patients with gout have short telomeres compared with healthy participants: association of telomere length with flare frequency and cardiovascular disease in gout
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DOI: 10.1136/annrheumdis-2016-210538
Abstract: Aim and background Chronic inflammation associates with increased senescence, which is a strong predictor for cardiovascular disease. We hypothesised that inflammation accelerates senescence and thereby enhances the risk of cardiovascular disease in gout. Methods We… read more here.
Keywords: healthy participants; telomere length; cardiovascular disease; disease gout ... See more keywords