Immune status of patients with haemophilia A before exposure to factor VIII: first results from the HEMFIL study
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DOI: 10.1111/bjh.14799
Abstract: Previous cross‐sectional studies showed that some patients with haemophilia A (HA) without inhibitor presented a pro‐inflammatory profile during factor VIII (FVIII) replacement therapy. Furthermore, an anti‐inflammatory/regulatory state was described in HA patients after inhibitor development.… read more here.
Keywords: patients haemophilia; status; factor viii; study ... See more keywords
Patients with haemophilia A with inhibitors in China: a national real‐world analysis and follow‐up
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DOI: 10.1111/bjh.17322
Abstract: The development of alloantibodies (inhibitors) against coagulation factor VIII (FVIII) is the most serious complication of FVIII replacement therapy in patients with haemophilia A (HA). We carried out a nationwide study focussing on patients with… read more here.
Keywords: real world; patients haemophilia; haemophilia inhibitors; china national ... See more keywords
Pharmacokinetics of a novel extended half‐life glycoPEGylated factor IX, nonacog beta pegol (N9‐GP) in previously treated patients with haemophilia B: results from two phase 3 clinical trials
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DOI: 10.1111/hae.13191
Abstract: Nonacog beta pegol (N9‐GP) is a glycoPEGylated recombinant factor IX (FIX) with an extended half‐life developed for routine prophylaxis and the prevention and treatment of bleeding episodes in patients with haemophilia B. read more here.
Keywords: extended half; patients haemophilia; beta pegol; nonacog beta ... See more keywords
Incidence of low‐titre factor VIII inhibitors in patients with haemophilia A: meta‐analysis of observational studies
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DOI: 10.1111/hae.13193
Abstract: A few studies have been focused on low‐titre inhibitors in patients with haemophilia A. Although several putative factors have been implicated in the development of these inhibitors, solid data are still lacking. read more here.
Keywords: incidence low; patients haemophilia; factor viii; inhibitors patients ... See more keywords
Platelet Rich Plasma for Chronic Synovitis Treatment in Patients with Haemophilia
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DOI: 10.1111/hae.13212
Abstract: Haemophilic synovitis is caused by chronic accumulation of blood in the joint. Conservative treatment is insufficient to solve this pathology. Platelet‐rich plasma (PRP) has a high concentration of growth factors (GFs) that play a key… read more here.
Keywords: synovitis; patients haemophilia; treatment; platelet rich ... See more keywords
Somatosensory profile of patients with haemophilia
Sign Up to like & getrecommendations! Published in 2018 at "Haemophilia"
DOI: 10.1111/hae.13370
Abstract: Patients with haemophilia (PwH) suffer from an enhanced pain sensitivity due to repetitive joint bleedings. A comprehensive, quantitative examination of the somatosensory system has not been performed in this population to date. read more here.
Keywords: patients haemophilia; somatosensory profile; haemophilia somatosensory; profile patients ... See more keywords
Clinical relevance of 3D gait analysis in patients with haemophilia
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DOI: 10.1111/hae.13563
Abstract: Haemophilia is characterized by a congenital deficiency of clotting factor VIII or IX. One of the consequences of haemophilia is joint bleedings. Repetitive haemathroses induce cartilage damage and chronic synovitis leading to joint deterioration, and… read more here.
Keywords: clinical relevance; patients haemophilia; gait analysis; analysis ... See more keywords
Real‐world comparative analysis of bleeding complications and health‐related quality of life in patients with haemophilia A and haemophilia B
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DOI: 10.1111/hae.13596
Abstract: Clinical severity and impact of haemophilia on quality of life have been generally considered to be lower for haemophilia B (HB) compared with haemophilia A (HA) patients. read more here.
Keywords: real world; patients haemophilia; world comparative; quality life ... See more keywords
Development and evaluation of appropriate, culturally adapted educational tools for Ivoirian patients with haemophilia, haemophilia carriers and their families
Sign Up to like & getrecommendations! Published in 2019 at "Haemophilia"
DOI: 10.1111/hae.13818
Abstract: Patient education is the cornerstone of the management of chronic diseases like haemophilia. The education of patients with haemophilia (PWH), haemophilia carriers and their families requires educational materials adapted to their socio‐cultural situations for maximum… read more here.
Keywords: patients haemophilia; evaluation appropriate; carriers families; haemophilia carriers ... See more keywords
Understanding the pain profile in patients with haemophilia: Impaired descending pain inhibition as measured by conditioned pain modulation
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DOI: 10.1111/hae.13939
Abstract: Haemophilic arthropathy is associated with pain that often becomes chronic, likely caused by peripheral and central mechanisms. In the field of haemophilia, to our knowledge, the role of the descending pain pathway, which can also… read more here.
Keywords: understanding pain; patients haemophilia; profile patients; pain profile ... See more keywords
Prevalence of inhibitors and clinical characteristics in patients with haemophilia in a middle‐income Latin American country
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DOI: 10.1111/hae.13951
Abstract: Development of inhibitors is the most serious complication in patients with haemophilia (PWH). The prevalence of inhibitors in patients with severe haemophilia A (HA) is approximately 25%‐30%. Inhibitor prevalence differs among populations. Some studies report… read more here.
Keywords: prevalence inhibitors; patients haemophilia; characteristics patients; prevalence ... See more keywords