A call for action: Increasing enrollment of untreated patients with higher‐risk myelodysplastic syndromes in first‐line clinical trials
Sign Up to like & getrecommendations! Published in 2017 at "Cancer"
DOI: 10.1002/cncr.30903
Abstract: Hypomethylating agents (HMAs) have changed the landscape of the management of patients with higher‐risk myelodysplastic syndromes (HR‐MDS). HMAs have improved hematopoiesis and quality of life and, in the case of azacitidine, prolonged survival in a… read more here.
Keywords: line; enrollment; patients higher; higher risk ... See more keywords
Adoptive transfer of neoantigen-specific T-cell therapy is feasible in older patients with higher-risk myelodysplastic syndrome.
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DOI: 10.1016/j.jcyt.2020.11.003
Abstract: BACKGROUND Myelodysplastic syndromes (MDS) represent the most common type of acquired bone marrow failure in adults and is characterized by ineffective maturation of myeloid precursor cells and peripheral cytopenias associated with higher rates of infection,… read more here.
Keywords: cell therapy; patients higher; higher risk; therapy ... See more keywords
Disparities in Outcomes by Insurance Payer Groups for Patients Undergoing Anterior Cervical Discectomy and Fusion.
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DOI: 10.1097/brs.0000000000003365
Abstract: STUDY DESIGN Retrospective, observational study of clinical outcomes at a single institution. OBJECTIVE To compare postoperative complication and readmission rates of payer groups in a cohort of patients undergoing anterior cervical discectomy and fusion (ACDF).… read more here.
Keywords: higher rates; commercial patients; patients higher; payer groups ... See more keywords
Keloid patients have higher peripheral blood endothelial progenitor cell counts and CD34+ cells with normal vasculogenic and angiogenic function that overexpress vascular endothelial growth factor and interleukin‐8
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Dermatology"
DOI: 10.1111/ijd.14575
Abstract: One suggested reason for aberrant wound healing in keloid scars is chronic inflammation of the dermis. We hypothesized that excessive blood vessel formation and high capillary density in keloid tissue is caused by dysfunction of… read more here.
Keywords: keloid patients; patients higher; endothelial progenitor; blood ... See more keywords
Circulating lymphocyte subsets as promising biomarkers to identify septic patients at higher risk of unfavorable outcome
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DOI: 10.1186/s12879-021-06481-1
Abstract: Background Early recognition of patients hospitalized for sepsis at higher risk of poor clinical outcome is a mandatory task and many studies suggested that indicators of the immune status may be useful for this purpose.… read more here.
Keywords: cd4 cells; patients higher; higher risk; lymphocyte subsets ... See more keywords
Which octogenarian patients are at higher risk after cholecystectomy for symptomatic gallstone disease? A single center cohort study
Sign Up to like & getrecommendations! Published in 2022 at "World Journal of Clinical Cases"
DOI: 10.12998/wjcc.v10.i24.8556
Abstract: BACKGROUND Incidence of gallstones in those aged ≥ 80 years is as high as 38%-53%. The decision-making process to select those oldest old patients who could benefit from cholecystectomy is challenging. AIM To assess the… read more here.
Keywords: higher risk; octogenarian patients; risk cholecystectomy; risk ... See more keywords
Clinical impact of transformation to acute myeloid leukemia in patients with higher-risk myelodysplastic syndromes.
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DOI: 10.2217/fon-2022-0334
Abstract: Aim: Forty percent of patients with higher-risk myelodysplastic syndromes (HR-MDS) transform to acute myeloid leukemia (AML). Materials & methods: This retrospective study assessed the impact of HR-MDS transformation to AML on OS in a 6-month landmark… read more here.
Keywords: higher risk; myelodysplastic syndromes; risk myelodysplastic; patients higher ... See more keywords
The recommended dosage regimen for caspofungin in patients with higher body weight or hypoalbuminaemia will result in low exposure: Five years of data based on a population pharmacokinetic model and Monte-Carlo simulations
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.993330
Abstract: Background: To develop a population pharmacokinetic (PPK) model for caspofungin, identify parameters influencing caspofungin pharmacokinetics, and assess the required probability of target attainment (PTA) and cumulative fraction of response (CFR) for various dosing regimens of… read more here.
Keywords: caspofungin patients; body weight; ppk; model ... See more keywords
Mortality and Major Cardiovascular Events among Patients with Multiple Myeloma: Analysis from a Nationwide French Medical Information Database
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DOI: 10.3390/cancers14133049
Abstract: Simple Summary No robust data exist on the cardiovascular risks of multiple myeloma (MM) patients. We used the French nationwide hospitalization database to assess the risk of all-cause death and cardiovascular events in unselected MM… read more here.
Keywords: higher risk; death; risk; patients higher ... See more keywords
Selected Predictors of COVID-19 Mortality in the Hospitalised Patient Population in a Single-Centre Study in Poland
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DOI: 10.3390/healthcare11050719
Abstract: Background: The correct analysis of COVID-19 predictors could substantially improve the clinical decision-making process and enable emergency department patients at higher mortality risk to be identified. Methods: We retrospectively explored the relationship between some demographic… read more here.
Keywords: rdw; mortality; covid mortality; patients higher ... See more keywords