Benzocaine-Associated Methemoglobinemia.
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Therapeutics"
DOI: 10.1097/mjt.0000000000000782
Abstract: of high-dose activated factor VII. Blood Coagul Fibrinolysis. 1998;9(suppl 1):S61–S65. 6. Turecek PL, Varadi K, Gritsch H et al. FEIBAs: mode of action. Haemophilia. 2004;10(suppl 2):3–9. 7. Shapiro AD, Hedner U. Advances in bypassing agent… read more here.
Keywords: haemophilia; patients inhibitors; associated methemoglobinemia; factor ... See more keywords
Inhibitors Significantly Impair Quality of Life for Hemophilia a Patients
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DOI: 10.1182/blood-2024-211342
Abstract: Background: Hemophilia A is a rare, inherited bleeding disorder that can severely affect a patient's quality of life (QoL) across all age groups. The development of inhibitors, antibodies that neutralize clotting factor therapies, may further… read more here.
Keywords: disease burden; quality life; patients inhibitors; hemophilia patients ... See more keywords
Single-cell sequencing on PBMCs from patients with HA and HB with inhibitors reveals different immune responses to FVIII and FIX
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DOI: 10.1182/bloodadvances.2025015799
Abstract: Key Points • Single-cell sequencing reveals differential immune responses to FVIII and FIX in patients with HA and HB.• B cells dominate in patients with HA with inhibitors, whereas T cells are relatively more active… read more here.
Keywords: cell sequencing; patients inhibitors; immune responses; single cell ... See more keywords
Hemophilia a patients with inhibitors: Mechanistic insights and novel therapeutic implications
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1019275
Abstract: The development of coagulation factor VIII (FVIII) inhibitory antibodies is a serious complication in hemophilia A (HA) patients after FVIII replacement therapy. Inhibitors render regular prophylaxis ineffective and increase the risk of morbidity and mortality.… read more here.
Keywords: hemophilia patients; inhibitors mechanistic; novel therapeutic; insights novel ... See more keywords