Assessment of Phase 3 Randomized Clinical Trials Including Patients With Leptomeningeal Disease: A Systematic Review.
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DOI: 10.1001/jamaoncol.2022.7364
Abstract: This systematic review examines the proportion of patients with leptomeningeal disease included in phase 3 randomized clinical trials for patients with metastatic breast cancer, lung cancer, and melanoma. read more here.
Keywords: clinical trials; systematic review; randomized clinical; phase randomized ... See more keywords
Intra‐CSF topotecan in treatment of breast cancer patients with leptomeningeal metastases
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DOI: 10.1002/cam4.3422
Abstract: There are few treatment options for patients with leptomeningeal metastases (LM). read more here.
Keywords: leptomeningeal metastases; csf topotecan; treatment; patients leptomeningeal ... See more keywords
Bedside ocular ultrasonography for diagnosing increased intracranial pressure in patients with leptomeningeal metastases from non‐small‐cell lung cancer
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DOI: 10.1002/cam4.5484
Abstract: To explore the diagnostic accuracy of ultrasound measurement of optic nerve sheath diameter (ONSD) and optic disc height (ODH) in detecting intracranial hypertension in non‐small‐cell lung cancer (NSCLC) patients with leptomeningeal metastases (LM). read more here.
Keywords: lung cancer; non small; small cell; patients leptomeningeal ... See more keywords
Single-arm, open-label phase 2 trial of pembrolizumab in patients with leptomeningeal carcinomatosis
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DOI: 10.1038/s41591-020-0918-0
Abstract: An increasing fraction of patients with metastatic cancer develop leptomeningeal dissemination of disease (LMD), and survival is dismal1–3. We conducted a single-arm, phase 2 study of pembrolizumab in patients with solid tumor malignancies and LMD… read more here.
Keywords: phase; pembrolizumab patients; patients leptomeningeal; single arm ... See more keywords
Leptomeningeal enhancement in magnetic resonance imaging predicts poor prognosis in lung adenocarcinoma patients with leptomeningeal metastasis
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DOI: 10.1111/1759-7714.14362
Abstract: To investigate the prognostic value of magnetic resonance imaging (MRI) findings in the prognosis of patients with leptomeningeal metastasis from lung adenocarcinoma. read more here.
Keywords: magnetic resonance; lung adenocarcinoma; resonance imaging; leptomeningeal metastasis ... See more keywords
Retrospective review of metastatic melanoma patients with leptomeningeal disease treated with intrathecal interleukin-2
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DOI: 10.1136/esmoopen-2017-000283
Abstract: Objectives Metastatic melanoma patients with leptomeningeal disease (LMD) have an extremely poor prognosis, with a median survival measured in weeks, and few treatment options. Outcomes of a retrospective cohort of patients with LMD that were… read more here.
Keywords: leptomeningeal disease; patients leptomeningeal; metastatic melanoma; melanoma patients ... See more keywords
Pembrolizumab for patients with leptomeningeal metastasis from solid tumors: efficacy, safety, and cerebrospinal fluid biomarkers
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DOI: 10.1136/jitc-2021-002473
Abstract: Background The benefit of immune checkpoint inhibitors (ICIs) in patients with leptomeningeal metastases (LMM) is unknown. Methods We undertook a phase II trial of pembrolizumab in patients with LMM from solid tumors. Eligible patients had… read more here.
Keywords: cns response; pembrolizumab patients; solid tumors; patients leptomeningeal ... See more keywords
Anti-PD-1 for patients with leptomeningeal metastasis from advanced solid tumors: Efficacy, safety, and biomarkers of response.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.e14506
Abstract: e14506Background: Leptomeningeal metastasis (LMM) from solid tumors are rare and often refractory to standard therapies. Pembrolizumab (anti-PD-1) has efficacy in patients (pts) with brain metastas... read more here.
Keywords: leptomeningeal metastasis; solid tumors; patients leptomeningeal; metastasis advanced ... See more keywords
Role of Systemic Immunoinflammation Landscape in the Overall Survival of Patients with Leptomeningeal Metastases from Lung Cancer
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DOI: 10.2147/ott.s402389
Abstract: Purpose Several biomarkers, such as baseline neutrophil-to-lymphocyte ratio (NLR), have been more investigated in patients with brain metastases (BM), while their role in patients with leptomeningeal metastases (LM) has not been clarified. Considering the difference… read more here.
Keywords: lung cancer; role; patients leptomeningeal; systemic immunoinflammation ... See more keywords
Impact of New Systemic Treatment and Radiotherapy in Melanoma Patients with Leptomeningeal Metastases
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DOI: 10.3390/cancers12092635
Abstract: Simple Summary Although the recent years have seen incredible progress in the treatment of advanced melanoma including brain metastases, the survival of melanoma patients with leptomeningeal disease (LM) is still poor. There are currently only… read more here.
Keywords: systemic treatment; treatment; patients leptomeningeal; new systemic ... See more keywords