Evaluation of the Association of Perioperative UGT1A1 Genotype-Dosed gFOLFIRINOX With Margin-Negative Resection Rates and Pathologic Response Grades Among Patients With Locally Advanced Gastroesophageal Adenocarcinoma: A Phase 2 Clinical Trial.
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DOI: 10.1001/jamanetworkopen.2019.21290
Abstract: Importance Patients with locally advanced gastroesophageal adenocarcinoma (ie, stage ≥T3 and/or node positive) have high rates of recurrence despite surgery and adjunctive perioperative therapies, which also have high toxicity profiles. Evaluation of pharmacogenomically dosed perioperative… read more here.
Keywords: ugt1a1 genotype; genotype; gastroesophageal; patients locally ... See more keywords
Poor tumor differentiation is an independent adverse prognostic variable in patients with locally advanced oral cavity cancer––Comparison with pathological risk factors according to the NCCN guidelines
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DOI: 10.1002/cam4.4195
Abstract: We sought to compare the prognostic impact of tumor differentiation with respect to adverse risk factors (RFs) identified by the National Comprehensive Cancer Network (NCCN) guidelines––including extranodal extension (ENE), positive/close margins, perineural invasion, lymphatic invasion,… read more here.
Keywords: nccn guidelines; risk factors; tumor differentiation; patients locally ... See more keywords
Phase 1 dose‐finding study of metformin in combination with concurrent cisplatin and radiotherapy in patients with locally advanced head and neck squamous cell cancer
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DOI: 10.1002/cncr.32539
Abstract: The 5‐year overall survival (OS) rate remains at 50% for patients with locally advanced head and neck squamous cell carcinoma (LAHNSCC), thereby underscoring the need for improved treatments. An antidiabetic agent, metformin, was found in… read more here.
Keywords: neck squamous; squamous cell; advanced head; patients locally ... See more keywords
Treatment outcomes of MRI-guided adaptive brachytherapy in patients with locally advanced cervical cancer: institutional experiences
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DOI: 10.1007/s00066-021-01887-x
Abstract: Image-guided adaptive brachytherapy (IGABT) is currently state of the art in the comprehensive treatment of patients with cervical cancer. Here, we report mature clinical data regarding IGABT of cervical cancer in a large patient sample,… read more here.
Keywords: cervical cancer; patients locally; guided adaptive; treatment ... See more keywords
Predictive factors of complete pathological response in patients with locally advanced rectal cancer
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DOI: 10.1007/s00384-020-03633-8
Abstract: Patients with locally advanced rectal cancer who achieve pathologic complete response (pCR) following neoadjuvant therapy have better long-term outcomes and could be spared from the perioperative and long-term morbidity of rectal resection. The aim of… read more here.
Keywords: rectal cancer; response; advanced rectal; patients locally ... See more keywords
Feasibility of neoadjuvant therapy for elderly patients with locally advanced rectal cancer
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DOI: 10.1007/s00595-019-01801-0
Abstract: PurposeThe feasibility of neoadjuvant therapy (NAT) for elderly patients with rectal cancer has not been evaluated well.MethodsBetween 2004 and 2014, 506 patients with locally advanced low rectal cancer underwent curative resection. Fifty-four were over 75 years… read more here.
Keywords: rectal cancer; received nat; group; elderly patients ... See more keywords
Gemcitabine Combined with the mTOR Inhibitor Temsirolimus in Patients with Locally Advanced or Metastatic Pancreatic Cancer. A Hellenic Cooperative Oncology Group Phase I/II Study
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DOI: 10.1007/s11523-018-0605-y
Abstract: BackgroundThe prognosis of patients with advanced pancreatic cancer is dismal, and there is a need for novel and effective treatments.ObjectivesTο determine the maximum tolerated dose (MTD) and dose-limiting toxicities (DLTs) of a novel gemcitabine (G)… read more here.
Keywords: phase; metastatic pancreatic; pancreatic cancer; patients locally ... See more keywords
Usefulness of Restaging Pelvis Magnetic Resonance Imaging After Neoadjuvant Concurrent Chemoradiotherapy in Patients With Locally Advanced Rectal Cancer.
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DOI: 10.1016/j.clcc.2020.06.006
Abstract: INTRODUCTION In patients with locally advanced rectal cancer, restaging pelvis magnetic resonance imaging (MRI) after neoadjuvant concurrent chemoradiotherapy is recommended despite its limited accuracy in predicting pathologic T (ypT) and N (ypN) stage. Neoadjuvant rectal… read more here.
Keywords: rectal cancer; advanced rectal; mnar; patients locally ... See more keywords
Early Tumor and Nodal Response in Patients with Locally Advanced Non-Small Cell Lung Carcinoma Predict for Oncologic Outcomes in Patients Treated with Concurrent Proton Therapy and Chemotherapy
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DOI: 10.1016/j.ijrobp.2019.10.019
Abstract: Purpose There are no established imaging biomarkers that predict response during chemoradiation for patients with locally advanced non-small cell lung carcinoma. At our institution, proton therapy (PT) patients undergo repeat computed tomography (CT) simulations twice… read more here.
Keywords: small cell; response; locally advanced; advanced non ... See more keywords
The effect of induction chemotherapy in patients with locally advanced nonsmall cell lung cancer who received chemoradiotherapy
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DOI: 10.1097/md.0000000000006165
Abstract: Background: The efficacy and toxicity of induction chemotherapy followed by concurrent chemoradiotherapy (CCRT) in patients with locally advanced nonsmall cell lung cancer (NSCLC) is unclear, we performed a systematic review and meta-analysis of published papers… read more here.
Keywords: chemotherapy; chemotherapy patients; ccrt; patients locally ... See more keywords
Total Neoadjuvant Therapy versus Standard Neoadjuvant Chemoradiation in Patients with Locally Advanced Rectal Cancer: A Comparison of Short- and Long-term Oncologic Outcomes.
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DOI: 10.1097/sla.0000000000005141
Abstract: OBJECTIVE To evaluate the impact of neoadjuvant multi-agent systemic chemotherapy and radiation (TNT) vs neoadjuvant single-agent chemoradiation (nCRT) and multi-agent adjuvant chemotherapy on overall survival (OS), tumor downstaging, and circumferential resection margin (CRM) status in… read more here.
Keywords: short long; locally advanced; rectal cancer; cancer ... See more keywords