Effectiveness of Genotype-Specific Tricyclic Antidepressant Dosing in Patients With Major Depressive Disorder
Sign Up to like & getrecommendations! Published in 2023 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2023.12443
Abstract: Key Points Question Does pharmacogenetics-informed (CYP2D6 and CYP2C19 genotypes) dosing of tricyclic antidepressants result in faster attainment of therapeutic plasma concentrations, higher effectiveness, and fewer and less severe adverse effects compared with usual treatment? Findings… read more here.
Keywords: effectiveness genotype; depressive disorder; patients major; major depressive ... See more keywords
Association of Brain Cortical Changes With Relapse in Patients With Major Depressive Disorder
Sign Up to like & getrecommendations! Published in 2018 at "JAMA Psychiatry"
DOI: 10.1001/jamapsychiatry.2018.0123
Abstract: Importance More than half of all patients with major depressive disorder (MDD) experience a relapse within 2 years after recovery. It is unclear how relapse affects brain morphologic features during the course of MDD. Objective… read more here.
Keywords: difference; volume; age; relapse ... See more keywords
Efficacy and Safety of Ketamine vs Electroconvulsive Therapy Among Patients With Major Depressive Episode: A Systematic Review and Meta-analysis.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA psychiatry"
DOI: 10.1001/jamapsychiatry.2022.3352
Abstract: Importance Whether ketamine is as effective as electroconvulsive therapy (ECT) among patients with major depressive episode remains unknown. Objective To systematically review and meta-analyze data about clinical efficacy and safety for ketamine and ECT in… read more here.
Keywords: review meta; ketamine; depressive episode; patients major ... See more keywords
Altered B Cell Homeostasis in Patients with Major Depressive Disorder and Normalization of CD5 Surface Expression on Regulatory B Cells in Treatment Responders
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuroimmune Pharmacology"
DOI: 10.1007/s11481-017-9763-4
Abstract: Pro-inflammatory activity and cell-mediated immune responses have been widely observed in patients with major depressive disorder (MDD). Besides their well-known function as antibody-producers, B cells play a key role in inflammatory responses by secreting pro-… read more here.
Keywords: cd5 surface; cell; surface expression; patients major ... See more keywords
Earlier Versus Later Augmentation with an Antipsychotic Medication in Patients with Major Depressive Disorder Demonstrating Inadequate Efficacy in Response to Antidepressants: A Retrospective Analysis of US Claims Data
Sign Up to like & getrecommendations! Published in 2018 at "Advances in Therapy"
DOI: 10.1007/s12325-018-0838-2
Abstract: IntroductionThere is little evidence regarding the most effective timing of augmentation of antidepressants (AD) with antipsychotics (AP) in patients with major depressive disorder (MDD) who inadequately respond to first-line AD (inadequate responders). The study’s objective… read more here.
Keywords: depressive disorder; disorder; major depressive; augmentation ... See more keywords
Gambling in patients with major depressive disorder is associated with an elevated risk of Suicide: Insights from 12-years of Nationwide inpatient sample data.
Sign Up to like & getrecommendations! Published in 2021 at "Addictive behaviors"
DOI: 10.1016/j.addbeh.2021.106872
Abstract: BACKGROUND There is a frequent occurrence of gambling disorder (GD) in patients with major depressive disorder (MDD). Psychiatric comorbidities can present more severely in patients diagnosed with pathological gambling. There is limited information on symptom… read more here.
Keywords: mdd patients; risk; diagnosis; disorder ... See more keywords
Efficacy and tolerability of pharmacological and non-pharmacological interventions in older patients with major depressive disorder: A systematic review, pairwise and network meta-analysis
Sign Up to like & getrecommendations! Published in 2019 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2019.07.130
Abstract: As there is currently no comprehensive evaluation about the efficacy and safety of interventions in elderly patients with major depressive disorder, we did a systematic review and network meta-analysis about all interventions in this population.… read more here.
Keywords: network meta; depressive disorder; patients major; major depressive ... See more keywords
Add-on benzodiazepine treatment in patients with major depressive disorder – results from a European cross-sectional multicenter study
Sign Up to like & getrecommendations! Published in 2020 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2020.09.636
Abstract: Since many patients with major depressive disorder (MDD) do not satisfactorily respond to initial antidepressant monotherapy, add-on treatment strategies with other psychiatric compounds are often established. The present European multicenter cross-sectional study comprising 1410 MDD… read more here.
Keywords: depressive disorder; treatment; disorder; study ... See more keywords
Alterations in patients with major depressive disorder before and after electroconvulsive therapy measured by fractional amplitude of low-frequency fluctuations (fALFF).
Sign Up to like & getrecommendations! Published in 2019 at "Journal of affective disorders"
DOI: 10.1016/j.jad.2018.10.099
Abstract: BACKGROUND Electroconvulsive therapy (ECT) is an important treatment option for patients with major depressive disorder (MDD). However, the mechanisms of ECT in MDD are still unclear. METHODS Twenty-four patients with severe MDD and 14 healthy… read more here.
Keywords: depressive disorder; ect; major depressive; gyrus ... See more keywords
Altered brain network in first-episode, drug-naive patients with major depressive disorder.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of affective disorders"
DOI: 10.1016/j.jad.2021.10.012
Abstract: BACKGROUND Resting-state functional magnetic resonance imaging has been widely used for the assessment of brain functional network, yet with inconsistent results. The present study aimed to investigate intranetwork and internetwork connectivity differences between patients with… read more here.
Keywords: depressive disorder; network; connectivity; major depressive ... See more keywords
Electroretinographic anomalies in medicated and drug free patients with major depression: Tagging the developmental roots of major psychiatric disorders
Sign Up to like & getrecommendations! Published in 2017 at "Progress in Neuro-Psychopharmacology and Biological Psychiatry"
DOI: 10.1016/j.pnpbp.2016.12.002
Abstract: ABSTRACT The retina is tagged as an approachable part of the brain due to its common embryonic origin and appears as a promising site of investigation for psychiatric disorders. Retinal function is assessed best with… read more here.
Keywords: mdd patients; psychiatric disorders; free patients; drug ... See more keywords