The impact of current treatment modalities on the outcomes of patients with melanoma brain metastases: A systematic review
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DOI: 10.1002/ijc.32696
Abstract: Patients with melanoma brain metastases (MBM) still have a very poor prognosis. Several treatment modalities have been investigated in an attempt to improve the management of MBM. This review aimed to evaluate the impact of… read more here.
Keywords: brain metastases; treatment modalities; treatment; therapy ... See more keywords
Association Between Immune-Related Adverse Events and Clinical Efficacy in Patients with Melanoma Treated With Nivolumab: A Multicenter Retrospective Study.
Sign Up to like & getrecommendations! Published in 2019 at "Clinical therapeutics"
DOI: 10.1016/j.clinthera.2018.11.004
Abstract: PURPOSE Nivolumab, an anti-programmed death 1 antibody, produces antitumor effects by activating host immunity, which also causes immune-related adverse events (irAEs). The aim of this study was to analyze the association between antitumor effect and… read more here.
Keywords: nivolumab treatment; group; study; iraes ... See more keywords
Analysis of NRAS gain in 657 patients with melanoma and evaluation of its sensitivity to a MEK inhibitor.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of cancer"
DOI: 10.1016/j.ejca.2017.11.011
Abstract: BACKGROUND Neuroblastoma rat-sarcoma (NRAS) mutations have been described in Chinese patients with melanoma. However, the status and the clinical significance of NRAS gain have not been investigated on a large scale. METHODS A total of… read more here.
Keywords: patients melanoma; nras gain; mek inhibitor;
Postdiagnosis aspirin use and overall survival in patients with melanoma
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Academy of Dermatology"
DOI: 10.1016/j.jaad.2017.12.076
Abstract: Background: Mouse studies show that tumor‐derived prostaglandins and platelets promote melanoma progression and immune evasion. Objective: Determine whether aspirin confers longer survival in patients with melanoma. Methods: A retrospective cohort study of 1522 patients at… read more here.
Keywords: aspirin; survival patients; aspirin use; overall survival ... See more keywords
Real-World EQ-5D-5L Utility Values In Patients With Melanoma Derived Using A Digital ‘Bring Your Own Device’ Platform
Sign Up to like & getrecommendations! Published in 2018 at "Value in Health"
DOI: 10.1016/j.jval.2018.04.301
Abstract: New treatments in melanoma are gradually transforming the disease into a chronic condition: • For advanced disease stages, the median survival has significantly increased (from 9 months in stage 4 patients with limited treatment options,… read more here.
Keywords: real world; world utility; utility values; melanoma derived ... See more keywords
Immunotherapy discontinuation — how, and when? Data from melanoma as a paradigm
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Clinical Oncology"
DOI: 10.1038/s41571-020-0399-6
Abstract: The optimal duration of therapy in patients receiving immune-checkpoint inhibitors (ICIs) is a new but crucial question that has arisen owing to the observation of durable remissions in >85% of patients with metastatic melanoma who… read more here.
Keywords: melanoma; long term; treatment; immunotherapy discontinuation ... See more keywords
Enriched circulating and tumor-resident TGF-β+ regulatory B cells in patients with melanoma promote FOXP3+ Tregs
Sign Up to like & getrecommendations! Published in 2022 at "Oncoimmunology"
DOI: 10.1080/2162402x.2022.2104426
Abstract: ABSTRACT B cells are emerging as key players of anti-tumor adaptive immune responses. We investigated regulatory and pro-inflammatory cytokine-expressing B cells in patients with melanoma by flow cytometric intracellular cytokine, CyTOF, transcriptomic, immunofluorescence, single-cell RNA-seq,… read more here.
Keywords: cell; tgf; tnf; patients melanoma ... See more keywords
Fertility preservation for patients with melanoma
Sign Up to like & getrecommendations! Published in 2022 at "Melanoma Research"
DOI: 10.1097/cmr.0000000000000840
Abstract: The advent of immunotherapy and targeted therapy has outstandingly improved the prognosis in subjects with melanoma. Their use is now advocated also in earlier stages as an adjuvant therapy, and some neoadjuvant clinical trials are… read more here.
Keywords: immunotherapy; preservation patients; fertility; patients melanoma ... See more keywords
The impact of sentinel lymph node mapping with hybrid single photon emission computed tomography/computed tomography in patients with melanoma. Comparison to planar radioisotopic lymphoscintigraphy
Sign Up to like & getrecommendations! Published in 2023 at "Melanoma Research"
DOI: 10.1097/cmr.0000000000000893
Abstract: We studied the diagnostic value of 16 slices of single photon emission computed tomography (SPECT)/computed tomography (CT) in the anatomical localization, image interpretation and extra-sentinel lymph nodes (SLNs) detection compared to dynamic and static planar… read more here.
Keywords: slns; computed tomography; spect; patients melanoma ... See more keywords
Cutaneous immune‐related adverse events in patients with melanoma treated with checkpoint inhibitors
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DOI: 10.1111/bjd.19750
Abstract: Checkpoint inhibitor (CPI) therapy has vastly improved long‐term outcomes in metastatic malignant melanoma (MMM). Therapy takes the form of monoclonal antibody infusions that target immune cell checkpoint proteins, such as cytotoxic T‐lymphocyte‐associated protein 4 (CTLA4)… read more here.
Keywords: immune related; cutaneous iraes; cutaneous immune; checkpoint ... See more keywords
729 The impact of immune and targeted therapies for melanoma in asian populations: a national cancer database analysis 2004–2016
Sign Up to like & getrecommendations! Published in 2020 at "Journal for ImmunoTherapy of Cancer"
DOI: 10.1136/jitc-2020-sitc2020.0729
Abstract: Background Immune checkpoint inhibitors (ICI) and targeted therapies (TT) have improved the survival outcomes in patients with advanced melanoma. However, less is known about their impact on Asian patients with melanoma. In this study, we… read more here.
Keywords: patients melanoma; asian patients; 2004 2016; national cancer ... See more keywords