Clinical Features and Outcomes of Black Patients with Melanoma.
Sign Up to like & getrecommendations! Published in 2024 at "JAMA dermatology"
DOI: 10.1001/jamadermatol.2023.5789
Abstract: Importance Melanoma in Black individuals has an annual incidence of approximately 1 in 100 000 people. Most studies of melanoma in Black patients have used population databases, which lack important, precise clinical details. Objective To identify… read more here.
Keywords: black patients; cutaneous melanomas; patients melanoma; history ... See more keywords
The impact of current treatment modalities on the outcomes of patients with melanoma brain metastases: A systematic review
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Cancer"
DOI: 10.1002/ijc.32696
Abstract: Patients with melanoma brain metastases (MBM) still have a very poor prognosis. Several treatment modalities have been investigated in an attempt to improve the management of MBM. This review aimed to evaluate the impact of… read more here.
Keywords: brain metastases; treatment modalities; treatment; therapy ... See more keywords
Association Between Immune-Related Adverse Events and Clinical Efficacy in Patients with Melanoma Treated With Nivolumab: A Multicenter Retrospective Study.
Sign Up to like & getrecommendations! Published in 2019 at "Clinical therapeutics"
DOI: 10.1016/j.clinthera.2018.11.004
Abstract: PURPOSE Nivolumab, an anti-programmed death 1 antibody, produces antitumor effects by activating host immunity, which also causes immune-related adverse events (irAEs). The aim of this study was to analyze the association between antitumor effect and… read more here.
Keywords: nivolumab treatment; group; study; iraes ... See more keywords
Analysis of NRAS gain in 657 patients with melanoma and evaluation of its sensitivity to a MEK inhibitor.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of cancer"
DOI: 10.1016/j.ejca.2017.11.011
Abstract: BACKGROUND Neuroblastoma rat-sarcoma (NRAS) mutations have been described in Chinese patients with melanoma. However, the status and the clinical significance of NRAS gain have not been investigated on a large scale. METHODS A total of… read more here.
Keywords: patients melanoma; nras gain; mek inhibitor;
Postdiagnosis aspirin use and overall survival in patients with melanoma
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Academy of Dermatology"
DOI: 10.1016/j.jaad.2017.12.076
Abstract: Background: Mouse studies show that tumor‐derived prostaglandins and platelets promote melanoma progression and immune evasion. Objective: Determine whether aspirin confers longer survival in patients with melanoma. Methods: A retrospective cohort study of 1522 patients at… read more here.
Keywords: aspirin; survival patients; aspirin use; overall survival ... See more keywords
Real-World EQ-5D-5L Utility Values In Patients With Melanoma Derived Using A Digital ‘Bring Your Own Device’ Platform
Sign Up to like & getrecommendations! Published in 2018 at "Value in Health"
DOI: 10.1016/j.jval.2018.04.301
Abstract: New treatments in melanoma are gradually transforming the disease into a chronic condition: • For advanced disease stages, the median survival has significantly increased (from 9 months in stage 4 patients with limited treatment options,… read more here.
Keywords: real world; world utility; utility values; melanoma derived ... See more keywords
Immunotherapy discontinuation — how, and when? Data from melanoma as a paradigm
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Clinical Oncology"
DOI: 10.1038/s41571-020-0399-6
Abstract: The optimal duration of therapy in patients receiving immune-checkpoint inhibitors (ICIs) is a new but crucial question that has arisen owing to the observation of durable remissions in >85% of patients with metastatic melanoma who… read more here.
Keywords: melanoma; long term; treatment; immunotherapy discontinuation ... See more keywords
Combining single-cell and bulk RNA sequencing to identify CAF-related signature for prognostic prediction and treatment response in patients with melanoma
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-14979-w
Abstract: Cancer-associated fibroblasts (CAFs) play complex roles in the tumor microenvironment (TME) of melanoma. However, their impact on prognosis and treatment response in melanoma remains unclear. In this study, ScRNA-seq data (GSE115978) were utilized to characterize… read more here.
Keywords: patients melanoma; single cell; treatment response; signature ... See more keywords
Enriched circulating and tumor-resident TGF-β+ regulatory B cells in patients with melanoma promote FOXP3+ Tregs
Sign Up to like & getrecommendations! Published in 2022 at "Oncoimmunology"
DOI: 10.1080/2162402x.2022.2104426
Abstract: ABSTRACT B cells are emerging as key players of anti-tumor adaptive immune responses. We investigated regulatory and pro-inflammatory cytokine-expressing B cells in patients with melanoma by flow cytometric intracellular cytokine, CyTOF, transcriptomic, immunofluorescence, single-cell RNA-seq,… read more here.
Keywords: cell; tgf; tnf; patients melanoma ... See more keywords
IMMU-49. Outcomes of SRS and Ipilimumab/Nivolumab Among Patients with Melanoma Brain Metastases
Sign Up to like & getrecommendations! Published in 2025 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaf201.0847
Abstract: While ipilimumab and nivolumab has demonstrated promising intracranial activity among patients with melanoma brain metastases (BM), patients with prior systemic therapy exposure may be at higher risk of poor intracranial disease control and benefit from… read more here.
Keywords: patients melanoma; brain; among patients; brain metastases ... See more keywords
Fertility preservation for patients with melanoma
Sign Up to like & getrecommendations! Published in 2022 at "Melanoma Research"
DOI: 10.1097/cmr.0000000000000840
Abstract: The advent of immunotherapy and targeted therapy has outstandingly improved the prognosis in subjects with melanoma. Their use is now advocated also in earlier stages as an adjuvant therapy, and some neoadjuvant clinical trials are… read more here.
Keywords: immunotherapy; preservation patients; fertility; patients melanoma ... See more keywords