Clinical Outcomes in Patients With Muscle-Invasive Urothelial Carcinoma Treated With Nivolumab
Sign Up to like & getrecommendations! Published in 2025 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2025.14427
Abstract: Key Points Question What is the clinical activity of adjuvant nivolumab in patients with high-risk muscle-invasive urothelial carcinoma in the community setting? Findings In this cohort study including 253 patients treated in a community setting,… read more here.
Keywords: urothelial carcinoma; clinical outcomes; muscle invasive; patients muscle ... See more keywords
FDA approves durvalumab for perioperative immunotherapy for patients with muscle‐invasive bladder cancer
Sign Up to like & getrecommendations! Published in 2025 at "Cancer"
DOI: 10.1002/cncr.35912
Abstract: This news section offers Cancer readers timely information on events, public policy analysis, topical issues, and personalities. In this issue, the FDA has approved the first perioperative immunotherapy (durvalumab) for patients with muscle‐invasive bladder cancer.… read more here.
Keywords: cancer; perioperative immunotherapy; muscle invasive; invasive bladder ... See more keywords
Renal function outcomes in patients with muscle‐invasive bladder cancer treated with neoadjuvant pembrolizumab and radical cystectomy in the PURE‐01 study
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Cancer"
DOI: 10.1002/ijc.33554
Abstract: The use of pembrolizumab has been largely accepted in several advanced types of cancers. PURE 01 study (NCT02736266) enrolled consecutively 143 patients with muscle‐invasive bladder cancer who received 3 cycles of pembrolizumab 200 mg every 3 weeks… read more here.
Keywords: muscle invasive; pure study; cancer; renal function ... See more keywords
Can Patients with Muscle-invasive Bladder Cancer and Fibroblast Growth Factor Receptor-3 Alterations Still Be Considered for Neoadjuvant Pembrolizumab? A Comprehensive Assessment from the Updated Results of the PURE-01 Study.
Sign Up to like & getrecommendations! Published in 2020 at "European urology oncology"
DOI: 10.1016/j.euo.2020.04.005
Abstract: In the PURE-01 study, patients with muscle-invasive bladder cancer (MIBC) who achieved a pathological complete response (CR; ypT0N0) had tumor features suggesting that pre-existing immunity may promote response. We focused on fibroblast growth factor receptor-3… read more here.
Keywords: bladder cancer; invasive bladder; muscle invasive; fgfr3 ... See more keywords
Two clusters of systemic lupus erythematosus patients with muscle involvement in a Chinese cohort
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Rheumatic Diseases"
DOI: 10.1111/1756-185x.14443
Abstract: This study aimed to depict the clinical features, including myositis specific or associated antibody (MSA/MAA) profile of systemic lupus erythematosus (SLE) patients with muscle involvement in a Chinese cohort. read more here.
Keywords: chinese cohort; involvement chinese; muscle involvement; systemic lupus ... See more keywords
Adjuvant pembrolizumab in genomically selected high-risk patients with muscle-invasive bladder cancer
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Oncology Pharmacy Practice"
DOI: 10.1177/10781552211016526
Abstract: Introduction Patients with muscle-invasive urothelial bladder cancer post neoadjuvant cisplatin-based chemotherapy with pathologic advanced disease (ypT3, ypT4, ypN+) at radical cystectomy have a significantly worse five-year overall survival. There is currently no preferred adjuvant therapy… read more here.
Keywords: cancer; risk; muscle invasive; bladder cancer ... See more keywords
Survival outcomes in elderly patients with muscle invasive bladder cancer: An analysis of the National Cancer Database.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.4538
Abstract: 4538Background: Many elderly patients are precluded from radical cystectomy (RC) due to existing comorbidities or morbidities associated with RC. Chemoradiation therapy (CRT) is an alternative trea... read more here.
Keywords: survival outcomes; muscle invasive; elderly patients; cancer ... See more keywords
Efficacy and biomarker analysis of neoadjuvant disitamab vedotin combined with immunotherapy in patients with muscle-invasive bladder cancer: A multi-center real-world study.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2024.42.23_suppl.113
Abstract: 113 Background: Over half of the patients with muscle-invasive bladder cancer (MIBC) do not benefit from neoadjuvant chemotherapy due to cisplatin intolerance or resistance and have a poor prognosis. Antibody-drug conjugates (ADCs) have shown excellent… read more here.
Keywords: analysis; muscle invasive; efficacy; patients muscle ... See more keywords
Platelet-to-lymphocyte ratio as a useful biomarker of recurrence and mortality risks in patients with muscle-invasive bladder cancer who achieved ypT0 to neoadjuvant chemotherapy: A multicenter retrospective study.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2025.43.5_suppl.873
Abstract: 873 Background: Platelet-to-lymphocyte ratio (PLR), a novel inflammatory marker, has been suggested to predict recurrence and mortality in several malignancies. Patients with muscle-invasive bladder cancer (MIBC) who achieved a pathological complete response (ypT0) to neoadjuvant… read more here.
Keywords: platelet lymphocyte; recurrence mortality; patients muscle; lymphocyte ratio ... See more keywords
A Pilot Study of Radiotherapy and Local Hyperthermia in Elderly Patients With Muscle-Invasive Bladder Cancers Unfit for Definitive Surgery or Chemoradiotherapy
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2019.00889
Abstract: Purpose: To present the outcomes of a pilot study with hyperthermia (HT) and radiotherapy (RT) in elderly patients of muscle-invasive bladder cancers (MIBC) unfit for surgery or chemoradiotherapy (CTRT). Methods: Sixteen elderly patients with unifocal… read more here.
Keywords: surgery; pilot study; muscle invasive; elderly patients ... See more keywords
Optimization of Preoperative Lymph Node Staging in Patients with Muscle-Invasive Bladder Cancer Using Radiomics on Computed Tomography
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Personalized Medicine"
DOI: 10.3390/jpm12050726
Abstract: Approximately 25% of the patients with muscle-invasive bladder cancer (MIBC) who are clinically node negative have occult lymph node metastases at radical cystectomy (RC) and pelvic lymph node dissection. The aim of this study was… read more here.
Keywords: invasive bladder; bladder cancer; lymph node; patients muscle ... See more keywords