Localizing deficits in white matter tracts of patients with narcolepsy with cataplexy: tract-specific statistical analysis
Sign Up to like & getrecommendations! Published in 2019 at "Brain Imaging and Behavior"
DOI: 10.1007/s11682-019-00100-z
Abstract: White matter alterations related to hypocretin pathway have been less evaluated in patients who have narcolepsy with cataplexy (NC), as compared to the identified exploration of gray matter and have varied among structural brain magnetic… read more here.
Keywords: tract specific; matter tracts; matter; patients narcolepsy ... See more keywords
Cytokines in narcolepsy: A systematic review and meta-analysis.
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DOI: 10.1016/j.cyto.2020.155103
Abstract: BACKGROUND Narcolepsy is a sleep disorder characterized by a loss of hypocretin neurons in the hypothalamus. Inflammation is proposed as a mechanism for neurodegeneration in narcolepsy. Numerous studies have investigated peripheral cytokine measures in narcoleptic… read more here.
Keywords: review meta; analysis; systematic review; patients narcolepsy ... See more keywords
Safety and efficacy of pitolisant on cataplexy in patients with narcolepsy: a randomised, double-blind, placebo-controlled trial
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DOI: 10.1016/s1474-4422(16)30333-7
Abstract: BACKGROUND Histaminergic neurons are crucial to maintain wakefulness, but their role in cataplexy is unknown. We assessed the safety and efficacy of pitolisant, a histamine H3 receptor inverse agonist, for treatment of cataplexy in patients… read more here.
Keywords: trial; treatment; group; patients narcolepsy ... See more keywords
501 Clinical PK of XW10172 for Once Nightly Therapy in Patients with Narcolepsy or Sleep Disorders in Neurodegenerative Diseases
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DOI: 10.1093/sleep/zsab072.500
Abstract: Patients with narcolepsy and patients with sleep disorders secondary to neurodegenerative diseases have been shown to respond to oxybate. To overcome the limitations of current oxybate therapies, we designed XW10172, a new chemical entity and… read more here.
Keywords: oxybate; sleep disorders; 501 clinical; xw10172 ... See more keywords
Once-Nightly Sodium Oxybate (FT218) Demonstrated Improvement of Symptoms in a Phase 3 Randomized Clinical Trial in Patients With Narcolepsy.
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DOI: 10.1093/sleep/zsab200
Abstract: STUDY OBJECTIVES To assess the efficacy and safety of FT218, a novel once-nightly formulation of sodium oxybate (ON-SXB), in patients with narcolepsy in the phase 3 REST-ON trial. METHODS Narcolepsy patients aged ≥16 years were… read more here.
Keywords: improvement; sxb; ft218; sodium oxybate ... See more keywords
Changes in Sleep Pattern During the COVID-19 Lockdown in Patients With Narcolepsy, Idiopathic Hypersomnia, and Restless Legs Syndrome
Sign Up to like & getrecommendations! Published in 2022 at "Neurology"
DOI: 10.1212/wnl.0000000000200907
Abstract: Background and Objectives To explore the first coronavirus disease 2019 (COVID-19) lockdown effect on sleep symptoms in patients with narcolepsy, idiopathic hypersomnia (IH), and restless legs syndrome (RLS). Methods Between March and May 2020, a… read more here.
Keywords: idiopathic hypersomnia; covid lockdown; hypersomnia restless; patients narcolepsy ... See more keywords
The relationship between orexin levels and blood pressure changes in patients with narcolepsy
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DOI: 10.1371/journal.pone.0185975
Abstract: Study objective Narcolepsy type 1 (NT1) is caused by a deficiency or absence of the neurotransmitter orexin. NT1 is also associated with a reduced nocturnal “dipping” of blood pressure (BP). The study objective was to… read more here.
Keywords: orexin levels; orexin; patients narcolepsy; blood pressure ... See more keywords
Dream Generation and Recall in Daytime NREM Sleep of Patients With Narcolepsy Type 1
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DOI: 10.3389/fnins.2020.608757
Abstract: The less rigid architecture of sleep in patients with narcolepsy type 1 (NT1) compared with healthy subjects may provide new insights into some unresolved issues of dream experience (DE), under the assumption that their DE… read more here.
Keywords: dream; narcolepsy type; sleep patients; sleep ... See more keywords
Medical comorbidities in Saudi patients with narcolepsy: a case-control study
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DOI: 10.5935/1984-0063.20200070
Abstract: Objective This case-control study sought to assess comorbid medical disorders in patients with narcolepsy type-1 (NT-1) and type-2 (NT-2). Material and Methods The study comprised 80 consecutive Arab (Saudi) patients with narcolepsy (NT-1=56 and NT-2=24)… read more here.
Keywords: saudi patients; patients narcolepsy; control study; case control ... See more keywords