Localizing deficits in white matter tracts of patients with narcolepsy with cataplexy: tract-specific statistical analysis
Sign Up to like & getrecommendations! Published in 2019 at "Brain Imaging and Behavior"
DOI: 10.1007/s11682-019-00100-z
Abstract: White matter alterations related to hypocretin pathway have been less evaluated in patients who have narcolepsy with cataplexy (NC), as compared to the identified exploration of gray matter and have varied among structural brain magnetic… read more here.
Keywords: tract specific; matter tracts; matter; patients narcolepsy ... See more keywords
Cytokines in narcolepsy: A systematic review and meta-analysis.
Sign Up to like & getrecommendations! Published in 2020 at "Cytokine"
DOI: 10.1016/j.cyto.2020.155103
Abstract: BACKGROUND Narcolepsy is a sleep disorder characterized by a loss of hypocretin neurons in the hypothalamus. Inflammation is proposed as a mechanism for neurodegeneration in narcolepsy. Numerous studies have investigated peripheral cytokine measures in narcoleptic… read more here.
Keywords: review meta; analysis; systematic review; patients narcolepsy ... See more keywords
Safety and efficacy of pitolisant on cataplexy in patients with narcolepsy: a randomised, double-blind, placebo-controlled trial
Sign Up to like & getrecommendations! Published in 2017 at "The Lancet Neurology"
DOI: 10.1016/s1474-4422(16)30333-7
Abstract: BACKGROUND Histaminergic neurons are crucial to maintain wakefulness, but their role in cataplexy is unknown. We assessed the safety and efficacy of pitolisant, a histamine H3 receptor inverse agonist, for treatment of cataplexy in patients… read more here.
Keywords: trial; treatment; group; patients narcolepsy ... See more keywords
Serum N-Glycan Profiling of Patients with Narcolepsy Type 1 Using LC-MS/MS
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DOI: 10.1021/acsomega.4c01593
Abstract: The neurological condition known as narcolepsy type 1 (NT1) is an uncommon condition marked by extreme daytime sleepiness, cataplexy, sleep paralysis, hallucinations, disrupted nocturnal sleep, and low or undetectable levels of orexin in the CSF… read more here.
Keywords: glycan biomarkers; glycan profiling; profiling patients; narcolepsy type ... See more keywords
501 Clinical PK of XW10172 for Once Nightly Therapy in Patients with Narcolepsy or Sleep Disorders in Neurodegenerative Diseases
Sign Up to like & getrecommendations! Published in 2021 at "Sleep"
DOI: 10.1093/sleep/zsab072.500
Abstract: Patients with narcolepsy and patients with sleep disorders secondary to neurodegenerative diseases have been shown to respond to oxybate. To overcome the limitations of current oxybate therapies, we designed XW10172, a new chemical entity and… read more here.
Keywords: oxybate; sleep disorders; 501 clinical; xw10172 ... See more keywords
Once-Nightly Sodium Oxybate (FT218) Demonstrated Improvement of Symptoms in a Phase 3 Randomized Clinical Trial in Patients With Narcolepsy.
Sign Up to like & getrecommendations! Published in 2021 at "Sleep"
DOI: 10.1093/sleep/zsab200
Abstract: STUDY OBJECTIVES To assess the efficacy and safety of FT218, a novel once-nightly formulation of sodium oxybate (ON-SXB), in patients with narcolepsy in the phase 3 REST-ON trial. METHODS Narcolepsy patients aged ≥16 years were… read more here.
Keywords: improvement; sxb; ft218; sodium oxybate ... See more keywords
0819 Insights from Physician Notes into Management of Patients with Narcolepsy Type 2 and Idiopathic Hypersomnia (IH)
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DOI: 10.1093/sleep/zsaf090.0819
Abstract: Narcolepsy and idiopathic hypersomnia (IH) are associated with diagnostic delays, comorbidities, and disease burden. Understanding how healthcare providers diagnose and treat patients could inform more timely and effective strategies for diagnosis and patient management. This… read more here.
Keywords: patients narcolepsy; work; physician notes; idiopathic hypersomnia ... See more keywords
0824 Characteristics of Patients with a Co-Morbid Narcolepsy Diagnosis Admitted to U.S. Hospitals: 20-year Trend
Sign Up to like & getrecommendations! Published in 2025 at "SLEEP"
DOI: 10.1093/sleep/zsaf090.0824
Abstract: Patients with narcolepsy are at risk for adverse health consequences, which may make them more vulnerable to hospital admissions. Moreover, narcolepsy can complicate the management of patients with other primary illnesses. There is scarce information… read more here.
Keywords: year; trend; risk; year period ... See more keywords
Eating disorders in narcolepsy type 1: Evidence from a cross‐sectional Italian study
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DOI: 10.1111/jsr.14150
Abstract: Narcolepsy type 1 is a chronic central disorder of hypersomnolence, and it is frequently accompanied by overweight, but the association between narcolepsy type 1 and eating disorders is controversial. Our study aims to compare patients… read more here.
Keywords: eating disorders; symptomatology; narcolepsy type; patients narcolepsy ... See more keywords
Changes in Sleep Pattern During the COVID-19 Lockdown in Patients With Narcolepsy, Idiopathic Hypersomnia, and Restless Legs Syndrome
Sign Up to like & getrecommendations! Published in 2022 at "Neurology"
DOI: 10.1212/wnl.0000000000200907
Abstract: Background and Objectives To explore the first coronavirus disease 2019 (COVID-19) lockdown effect on sleep symptoms in patients with narcolepsy, idiopathic hypersomnia (IH), and restless legs syndrome (RLS). Methods Between March and May 2020, a… read more here.
Keywords: idiopathic hypersomnia; covid lockdown; hypersomnia restless; patients narcolepsy ... See more keywords
The relationship between orexin levels and blood pressure changes in patients with narcolepsy
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0185975
Abstract: Study objective Narcolepsy type 1 (NT1) is caused by a deficiency or absence of the neurotransmitter orexin. NT1 is also associated with a reduced nocturnal “dipping” of blood pressure (BP). The study objective was to… read more here.
Keywords: orexin levels; orexin; patients narcolepsy; blood pressure ... See more keywords