Copenhagen Prospective Personalized Oncology (CoPPO)—Clinical Utility of Using Molecular Profiling to Select Patients to Phase I Trials
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DOI: 10.1158/1078-0432.ccr-18-1780
Abstract: Purpose: We evaluated the clinical benefit of tumor molecular profiling to select treatment in the phase I setting. Experimental Design: Patients with advanced solid cancers and exhausted treatment options referred to a phase I unit… read more here.
Keywords: treatment; molecular profiling; patients phase; select patients ... See more keywords
Clinical Efficacy of Intracellular Molecular Inhibitors for Relapsed, Refractory Multiple Myeloma: A Systematic Review of Early Clinical Data
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DOI: 10.1182/blood-2018-99-111587
Abstract: Introduction: Intracellular molecular inhibitors act by inducing apoptosis due to inhibition of intracellular proteins like 20S proteasome subunit, histone deacetylases (HDAC's), exportin 1 (XPO1), cyclin-dependent kinases (CDKs) and kinesin spindle protein (KSP). These proteins are… read more here.
Keywords: combination; rrmm patients; patients phase; intracellular molecular ... See more keywords