Response to Alpelisib in Clinically Distinct Pediatric Patients With PIK3CA-related Disorders.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of pediatric hematology/oncology"
DOI: 10.1097/mph.0000000000002418
Abstract: PIK3CA-related disorders include vascular malformations, potential overgrowth of various tissues, limb abnormalities, disordered soft tissue, and/or fatty hyperplasia that often leads to significant morbidity. Alpelisib, a targeted inhibitor of p110α, an enzyme encoded by the… read more here.
Keywords: patients pik3ca; pik3ca related; response alpelisib; clinically distinct ... See more keywords
Genotypes and phenotypes heterogeneity in PIK3CA-related overgrowth spectrum and overlapping conditions: 150 novel patients and systematic review of 1007 patients with PIK3CA pathogenetic variants
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Genetics"
DOI: 10.1136/jmedgenet-2021-108093
Abstract: Background Postzygotic activating PIK3CA variants cause several phenotypes within the PIK3CA-related overgrowth spectrum (PROS). Variant strength, mosaicism level, specific tissue involvement and overlapping disorders are responsible for disease heterogeneity. We explored these factors in 150… read more here.
Keywords: 150 novel; novel patients; patients pik3ca; pik3ca related ... See more keywords
Abstract P1-18-18: Real-world natural history data among patients with PIK3CA-mutant and PIK3CA-wild-type advanced breast cancer
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DOI: 10.1158/1538-7445.sabcs21-p1-18-18
Abstract: Background: Oncogenic mutations involving PIK3CA gene (PI3Kα) are observed in over 40% of patients with hormone receptor-positive (HR+) advanced breast cancer (ABC). Clinical efficacy of PI3K inhibition was demonstrated in a recent trial, but data… read more here.
Keywords: patients pik3ca; breast cancer; line; among patients ... See more keywords
FSCN1 Promotes Radiation Resistance in Patients With PIK3CA Gene Alteration
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DOI: 10.3389/fonc.2021.653005
Abstract: Radiotherapy is one of the standard treatments for cervical cancer and head and neck cancer. However, the clinical efficacy of this treatment is limited by radioresistance. The discovery of effective prognostic biomarkers and the identification… read more here.
Keywords: radiation resistance; promotes radiation; patients pik3ca; fscn1 promotes ... See more keywords