Evaluation of Comparative Surveillance Strategies of Circulating Tumor DNA, Imaging, and Carcinoembryonic Antigen Levels in Patients With Resected Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.1093
Abstract: Key Points Question Is serial analysis of circulating tumor DNA (ctDNA) associated with improved sensitivity and earlier detection of recurrence compared with standard imaging and evaluation of carcinoembryonic antigen (CEA) levels per National Comprehensive Cancer… read more here.
Keywords: circulating tumor; resected colorectal; colorectal cancer; tumor dna ... See more keywords
Association of Alterations in Main Driver Genes With Outcomes of Patients With Resected Pancreatic Ductal Adenocarcinoma
Sign Up to like & getrecommendations! Published in 2018 at "JAMA Oncology"
DOI: 10.1001/jamaoncol.2017.3420
Abstract: Importance Although patients with resected pancreatic adenocarcinoma are at high risk for disease recurrence, few biomarkers are available to inform patient outcomes. Objective To evaluate the alterations of the 4 main driver genes in pancreatic… read more here.
Keywords: patients resected; driver genes; resected pancreatic; pancreatic adenocarcinoma ... See more keywords
Alterations in driver genes are predictive of survival in patients with resected pancreatic ductal adenocarcinoma.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer"
DOI: 10.1002/cncr.33038
Abstract: BACKGROUND KRAS, TP53, CDKN2A, and SMAD4 are established driver genes in pancreatic ductal adenocarcinoma (PDAC). This study was aimed at determining whether the mutational status of driver genes and those involved in DNA repair pathways… read more here.
Keywords: patients resected; driver genes; months months; pancreatic ductal ... See more keywords
Impact of S‐1 adjuvant chemotherapy longer than 6 months on survival in patients with resected pancreatic cancer: a nationwide survey by the Japan Pancreas Society based on real‐world data
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DOI: 10.1002/cncr.34580
Abstract: Based on the Japan Adjuvant Study Group of Pancreatic Cancer 01 study, the standard duration of adjuvant chemotherapy with S‐1 (an oral 5‐fluorouracil prodrug consisting of tegafur, gimeracil, and oteracil) in patients with resected pancreatic… read more here.
Keywords: pancreatic cancer; resected pancreatic; adjuvant chemotherapy; real world ... See more keywords
Patterns of disease relapse and posttreatment follow‐up of patients with resected pancreatic adenocarcinoma: A single‐center analysis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Surgical Oncology"
DOI: 10.1002/jso.26985
Abstract: To describe the patterns of disease relapse and follow‐up of patients with resected pancreatic adenocarcinoma. Additionally, we looked at patients' characteristics at relapse and survival. read more here.
Keywords: follow patients; resected pancreatic; pancreatic adenocarcinoma; disease relapse ... See more keywords
Tumour grade and primary site predict patterns of recurrence and survival in patients with resected gastroenteropancreatic neuroendocrine tumors.
Sign Up to like & getrecommendations! Published in 2021 at "American journal of surgery"
DOI: 10.1016/j.amjsurg.2021.03.027
Abstract: BACKGROUND Patterns of recurrence help to inform surveillance of patients with resected gastroenteropancreatic neuroendocrine tumors (GEP-NETs). METHODS Patients with GEP-NETs in British Columbia, Canada (2004-2015) were reviewed. Associations between tumor characteristics, recurrence and survival were… read more here.
Keywords: patients resected; recurrence; resected gastroenteropancreatic; patterns recurrence ... See more keywords
Quality of life and mental health in real-world patients with resected stage III/IV melanoma receiving adjuvant immunotherapy
Sign Up to like & getrecommendations! Published in 2023 at "Acta Oncologica"
DOI: 10.1080/0284186x.2023.2165449
Abstract: Abstract Introduction Treatment with immune checkpoint inhibitors (ICI) has expanded into the adjuvant setting enhancing the importance of knowledge on the immune-related toxicities and their impact on health-related quality of life (HRQoL). Large phase 3… read more here.
Keywords: months ago; status; treatment months; hrqol ... See more keywords
Clinical efficacy of adjuvant treatments for patients with resected biliary tract cancer: a systematic review and network meta-analysis
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DOI: 10.1136/bmjopen-2021-051421
Abstract: Objective This study aimed to determine the benefits of adjuvant therapy in patients with resected biliary tract cancer (BTC) and identify the optimal adjuvant treatment scheme. Design Systematic review and network meta-analysis. Data sources Studies… read more here.
Keywords: network meta; meta analysis; patients resected;
Financial Toxicity in Patients with Resected Lung Cancer.
Sign Up to like & getrecommendations! Published in 2023 at "Annals of surgery"
DOI: 10.1158/1538-7445.am2023-726
Abstract: OBJECTIVES We aimed to describe financial toxicity (FT) in patients with resected lung cancer and identify risk factors in this population. SUMMARY BACKGROUND FT describes the financial burden associated with cancer care and its impact… read more here.
Keywords: lung cancer; financial toxicity; resected lung; patients resected ... See more keywords
Abstract LB197: A pooled mutant KRAS peptide vaccine activates polyfunctional T cell responses in patients with resected pancreatic cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-lb197
Abstract: Background: Oncogenic mutations in KRAS are expressed in up to 90% of pancreatic ductal adenocarcinomas (PDAC). Vaccination against mutant KRAS (mKRAS) is thus a promising approach as an off-the-shelf immunotherapeutic treatment for PDAC. We developed… read more here.
Keywords: mkras specific; cell; mutant kras; peptide vaccine ... See more keywords
Abstract LB199: A personalized neoantigen vaccine is well tolerated and induces specific T-cell immune response in patients with resected melanoma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-lb199
Abstract: Tumor mutations giving rise to neoantigens have recently emerged as promising targets for cancer immunotherapy. Vaccines delivering tumor-specific neoantigens have demonstrated favorable efficacy and safety results in numerous preclinical and early clinical studies. However, selecting… read more here.
Keywords: neoantigen vaccine; cell; well tolerated; neoantigen ... See more keywords