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Published in 2020 at "Journal of Pediatric Hematology/Oncology"
DOI: 10.1097/mph.0000000000001828
Abstract: To the Editor: Sickle cell disease (SCD) affects ~100,000 people in the United States, of which 36,000 are children.1 SCD is characterized by vaso-occlusive pain crises, with those pain crises leading to high emergency department…
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Keywords:
patients scd;
visits patients;
children scd;
sickle cell ... See more keywords
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Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-115973
Abstract: Introduction: Gene therapy is a highly promising therapeutic strategy in sickle cell disease (SCD). The Phase 1/2 HGB-205 (NCT02151526) clinical study in France is evaluating the safety and efficacy of LentiGlobin gene therapy, which consists…
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Keywords:
lentiglobin gene;
gene therapy;
hgb 205;
patients scd ... See more keywords
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Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-119778
Abstract: Introduction: It is estimated that there are 100,000 Americans living with Sickle Cell Disease (SCD). Patients with SCD experience a number of complications that frequently require hospitalization. SCD is a prothrombotic state that is commonly…
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Keywords:
vte;
mortality;
length stay;
patients scd ... See more keywords
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Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-122113
Abstract: Patients with sickle cell disease (SCD) experience accelerated morbidity and mortality. Venous thromboembolism (VTE), a risk factor for early mortality in SCD, occurs in 11-12% of patients with SCD by the age of 40. While…
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Keywords:
anticoagulation;
treatment;
venous thromboembolism;
cell disease ... See more keywords
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Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-132215
Abstract: Introduction The overall impact of morbidity related to sickle cell disease (SCD) is enormous due to decreased quality of life, high health care utilization and immense financial strain on the patients and health care system.…
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Keywords:
day readmission;
readmission;
study;
patients scd ... See more keywords
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Published in 2020 at "Blood"
DOI: 10.1182/blood-2020-136661
Abstract: Introduction:Significant morbidity and mortality in patients with sickle cell disease (SCD) is attributed to the pulmonary sequalae of the disease. Patients with SCD often suffer airway hyper-reactivity, acute chest syndrome (ACS), chronic lung disease, pulmonary…
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Keywords:
patients sickle;
patients scd;
iron levels;
iron ... See more keywords
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Published in 2020 at "Blood"
DOI: 10.1182/blood-2020-143441
Abstract: Background: Patients with sickle cell disease (SCD) are at increased risk of developing bacterial infections as a result of functional asplenia. Fever, a common symptom in SCD often occurs with other sickle cell related conditions…
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Keywords:
pct;
patients sickle;
viral infections;
patients scd ... See more keywords
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1
Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.931925
Abstract: Background L-glutamine has been shown to play an important role in the regulation of oxidative stress which is one of the key contributors to the pathophysiology of sickle cell disease (SCD). In a Phase 3…
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Keywords:
efficacy glutamine;
patients scd;
related complications;
cell disease ... See more keywords
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Published in 2022 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.888174
Abstract: Back ground Subjective cognitive decline (SCD) may be the first clinical sign of Alzheimer’s disease (AD). The possible neural mechanisms of SCD are not well known. This study aimed to compare percent amplitude of fluctuation…
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Keywords:
patients scd;
covariance;
study;
subjective cognitive ... See more keywords