Clinical characteristics and overall survival among acute myeloid leukemia patients with TP53 gene mutation or chromosome 17p deletion.
Sign Up to like & getrecommendations! Published in 2023 at "American journal of hematology"
DOI: 10.1002/ajh.26941
Abstract: Approximately 5% to 15% of acute myeloid leukemia (AML) patients have TP53 gene mutations (TP53m), which are associated with very poor outcomes. Adults (≥18 years) with a new AML diagnosis were included from a nationwide, de-identified,… read more here.
Keywords: myeloid leukemia; tp53 gene; patients tp53; acute myeloid ... See more keywords
Disparities in receiving disease‐directed therapy, allogeneic stem cell transplantation in non‐Hispanic Black patients with TP53‐mutated acute myeloid leukemia
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DOI: 10.1002/cncr.34604
Abstract: Although the clinical outcomes of patients with TP53‐mutated acute myeloid leukemia (AML) are dismal, subsets of patients eligible for curative‐intent therapies may fare better. Because racial disparities are known to affect outcome in hematologic malignancies,… read more here.
Keywords: mutated acute; myeloid leukemia; patients tp53; acute myeloid ... See more keywords
Clinical Features of Pediatric Acute Myeloid Leukemia with TP53 and CDKN2A/2B copy Number Alterations
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DOI: 10.1182/blood-2019-126263
Abstract: [Background] Customized gene panel sequencing is commonly used in cancer research to detect point mutations and small insertions or deletions. This technique can also be used to detect copy number alterations (CNAs) in tumor samples… read more here.
Keywords: copy number; patients tp53; cdkn2a alterations; tp53 losses ... See more keywords
Pevonedistat with azacitidine in older patients with TP53-mutated AML: a phase 2 study with laboratory correlates
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DOI: 10.1182/bloodadvances.2022008625
Abstract: Finding safe and effective treatment strategies for patients with TP53 -mutated acute myeloid leukemia (AML) remains an important unmet need. read more here.
Keywords: mutated aml; older patients; patients tp53; pevonedistat azacitidine ... See more keywords
Are We Moving the Needle for Patients with TP53-Mutated Acute Myeloid Leukemia?
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DOI: 10.3390/cancers14102434
Abstract: Simple Summary TP53-mutated acute myeloid leukemia (AML) represents one of the most informative examples of adverse risk AML. As the currently available therapies have not translated to meaningful advances in the survival of these patients,… read more here.
Keywords: mutated acute; myeloid leukemia; patients tp53; acute myeloid ... See more keywords