Pattern mixture models for clinical validation of biomarkers in the presence of missing data.
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DOI: 10.1002/sim.7328
Abstract: Targeted therapies for cancers are sometimes only effective in a subset of patients with a particular biomarker status. In clinical development, the biomarker status is typically determined by an investigational-use-only/laboratory-developed test. A market ready test… read more here.
Keywords: biomarker status; biomarker; pattern mixture; clinical validation ... See more keywords