Acute moderate exercise improves mnemonic discrimination in young adults
Sign Up to like & getrecommendations! Published in 2017 at "Hippocampus"
DOI: 10.1002/hipo.22695
Abstract: Increasing evidence suggests that regular moderate exercise increases neurogenesis in the dentate gyrus (DG) of the hippocampus and improves memory functions in both humans and animals. The DG is known to play a role in… read more here.
Keywords: pattern separation; mnemonic discrimination; exercise improves; moderate exercise ... See more keywords
The effects of sleep on the neural correlates of pattern separation [Hippocampus, 28(2), 108–120 (2018)]
Sign Up to like & getrecommendations! Published in 2019 at "Hippocampus"
DOI: 10.1002/hipo.23038
Abstract: FIGURE 1 A whole-brain voxel-wise analysis revealed a significant interaction between delay and group in several regions including the right DLPFC and inferior parietal lobule (a). fMRI activation decreased across a 12-hr delay for the… read more here.
Keywords: separation hippocampus; sleep neural; pattern separation; effects sleep ... See more keywords
Molecular mechanisms within the dentate gyrus and the perirhinal cortex interact during discrimination of similar nonspatial memories
Sign Up to like & getrecommendations! Published in 2020 at "Hippocampus"
DOI: 10.1002/hipo.23269
Abstract: Differentiating between similar memories is a crucial cognitive function that enables correct episodic memory formation. The ability to separate the components of memories into distinct representations is thought to rely on a computational process known… read more here.
Keywords: molecular mechanisms; dentate gyrus; memory; pattern separation ... See more keywords
APOE moderates the effect of hippocampal blood flow on memory pattern separation in clinically normal older adults
Sign Up to like & getrecommendations! Published in 2021 at "Hippocampus"
DOI: 10.1002/hipo.23327
Abstract: Pattern separation, the ability to differentiate new information from previously experienced similar information, is highly sensitive to hippocampal structure and function and declines with age. Functional MRI studies have demonstrated hippocampal hyperactivation in older adults… read more here.
Keywords: blood flow; normal older; pattern separation; separation ... See more keywords
Pattern separation in the hippocampus: distinct circuits under different conditions
Sign Up to like & getrecommendations! Published in 2018 at "Brain Structure and Function"
DOI: 10.1007/s00429-018-1659-4
Abstract: Pattern separation is a fundamental hippocampal process thought to be critical for distinguishing similar episodic memories, and has long been recognized as a natural function of the dentate gyrus (DG), supporting autoassociative learning in CA3.… read more here.
Keywords: separation hippocampus; pattern separation; separation; distinct circuits ... See more keywords
Dendritic Kv4.2 potassium channels selectively mediate spatial pattern separation in the dentate gyrus
Sign Up to like & getrecommendations! Published in 2021 at "iScience"
DOI: 10.1016/j.isci.2021.102876
Abstract: Summary The capacity to distinguish comparable experiences is fundamental for the recall of similar memories and has been proposed to require pattern separation in the dentate gyrus (DG). However, the cellular mechanisms by which mature… read more here.
Keywords: pattern separation; separation dentate; spatial pattern; separation ... See more keywords
Age-related vulnerability of pattern separation in C57BL/6J mice
Sign Up to like & getrecommendations! Published in 2018 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2017.10.013
Abstract: Aging is associated with impaired performance in behavioral pattern separation (PS) tasks based on similarities in object features and in object location. These deficits have been attributed to functional alterations in the dentate gyrus (DG)-CA3… read more here.
Keywords: c57bl mice; pattern separation; age; mice ... See more keywords
Impaired spatial pattern separation performance in temporal lobe epilepsy is associated with visuospatial memory deficits and hippocampal volume loss
Sign Up to like & getrecommendations! Published in 2018 at "Neuropsychologia"
DOI: 10.1016/j.neuropsychologia.2018.02.009
Abstract: ABSTRACT Individuals with chronic temporal lobe epilepsy (TLE) experience episodic memory deficits that may be progressive in nature. These memory decrements have been shown to increase with the extent of hippocampal damage, a hallmark feature… read more here.
Keywords: separation performance; pattern separation; spatial pattern; separation ... See more keywords
Mnemonic discrimination of object and context is differentially associated with mental health
Sign Up to like & getrecommendations! Published in 2020 at "Neurobiology of Learning and Memory"
DOI: 10.1016/j.nlm.2020.107268
Abstract: Episodic memories are formed by hippocampal binding of the "what" and "where" features of everyday events. The hippocampus minimizes interference between related similar episodic memories by pattern separation. Stress and psychopathology are associated with lowered… read more here.
Keywords: pattern separation; mental health; object context;
On pattern separation in the primate, including human, hippocampus
Sign Up to like & getrecommendations! Published in 2021 at "Trends in Cognitive Sciences"
DOI: 10.1016/j.tics.2021.07.004
Abstract: In a recent article, Quiroga argued that pattern separation may not occur in the human hippocampus [1]. This argument was based on neuronal recordings in the human hippocampus that showed that many neurons respond to… read more here.
Keywords: pattern separation; human hippocampus; separation; separation primate ... See more keywords
The impact of context on pattern separation for objects among younger and older apolipoprotein ϵ4 carriers and noncarriers
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the International Neuropsychological Society"
DOI: 10.1017/s1355617722000455
Abstract: Abstract Objective: On continuous recognition tasks, changing the context objects are embedded in impairs memory. Older adults are worse on pattern separation tasks requiring identification of similar objects compared to younger adults. However, how contexts… read more here.
Keywords: older adults; carriers noncarriers; pattern separation; among younger ... See more keywords