G-protein Biased Signaling Agonists of Dopamine D3 Receptor Promote Distinct Activation Patterns of ERK1/2.
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DOI: 10.1016/j.phrs.2022.106223
Abstract: Dopamine D3 receptors (D3R) have a causal role in neurological and psychiatric disorders. We have developed a novel class of G-protein biased (GPB) signaling D3R agonists with minimal β-arrestin2 (βarr2) recruitment and demonstrated efficacy in… read more here.
Keywords: activation; protein biased; phosphorylation; gpb agonists ... See more keywords