Transferability of Geometric Patterns from Protein Self-Interactions to Protein-Ligand Interactions
Sign Up to like & getrecommendations! Published in 2022 at "Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing"
DOI: 10.1101/2021.10.01.462692
Abstract: There is significant interest in developing machine learning methods to model protein-ligand interactions but a scarcity of experimentally resolved protein-ligand structures to learn from. Protein self-contacts are a much larger source of structural data that… read more here.
Keywords: protein self; geometric patterns; protein ligand; patterns protein ... See more keywords
Predicting synthetic lethal interactions using conserved patterns in protein interaction networks
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1006888
Abstract: In response to a need for improved treatments, a number of promising novel targeted cancer therapies are being developed that exploit human synthetic lethal interactions. This is facilitating personalised medicine strategies in cancers where specific… read more here.
Keywords: patterns protein; lethal interactions; topology; conserved patterns ... See more keywords