Overview of PAX gene family: analysis of human tissue-specific variant expression and involvement in human disease
Sign Up to like & getrecommendations! Published in 2020 at "Human Genetics"
DOI: 10.1007/s00439-020-02212-9
Abstract: Paired-box (PAX) genes encode a family of highly conserved transcription factors found in vertebrates and invertebrates. PAX proteins are defined by the presence of a paired domain that is evolutionarily conserved across phylogenies. Inclusion of… read more here.
Keywords: tissue specific; tissue; pax proteins; variant expression ... See more keywords
Pax-5 Inhibits NF-κB Activity in Breast Cancer Cells Through IKKε and miRNA-155 Effectors
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Mammary Gland Biology and Neoplasia"
DOI: 10.1007/s10911-018-9404-4
Abstract: Pax-5, an essential transcription factor in B cell development, is aberrantly expressed in various B cell cancer lesions and solid tumors such as breast carcinoma. We have recently shown that Pax-5 regulates NF-κB activity which… read more here.
Keywords: breast cancer; cancer cells; cancer; activity ... See more keywords
Paclitaxel Promotes Oxidative Stress-Mediated Human Laryngeal Squamous Tumor Cell Death through the Stimulation of Calcium and Zinc Signaling Pathways: No Synergic Action of Melatonin.
Sign Up to like & getrecommendations! Published in 2022 at "Biological trace element research"
DOI: 10.1007/s12011-022-03125-6
Abstract: The paclitaxel (PAX) and melatonin (MLT)-mediated mitochondria reactive free oxygen radical (miROS) generations via the influx of excessive Ca2+ and Zn2+ induce tumor cell death and apoptosis. However, a presence of resistance was demonstrated against… read more here.
Keywords: mlt; treatment; pax; cell death ... See more keywords
Inhibition of aldehyde dehydrogenase-1 and p-glycoprotein-mediated multidrug resistance by curcumin and vitamin D3 increases sensitivity to paclitaxel in breast cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2019.108865
Abstract: Treatment of breast cancer by paclitaxel (PAX) often encounters therapeutic failure most likely caused by innate/acquired resistance. Cancer stem cells (CSCs) and multidrug resistance complex (MDR-1 or P-glycoprotein) overexpression are main mechanisms implicated in chemoresistance.… read more here.
Keywords: resistance; pax; cur; breast cancer ... See more keywords
Effects of chemical and processing variables on paclitaxel-loaded polymer nanoparticles prepared using microfluidics.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of colloid and interface science"
DOI: 10.1016/j.jcis.2017.08.053
Abstract: For paclitaxel (PAX)-loaded polymeric nanoparticles PNPs prepared in a two-phase gas-liquid microfluidic reactor, the effects of microfluidic flow rate on the multiscale structure, loading efficiency and release rate are determined for three different copolymer compositions… read more here.
Keywords: pcl block; flow rate; rate; pax ... See more keywords
Are Pax proteins potential therapeutic targets in kidney disease and cancer?
Sign Up to like & getrecommendations! Published in 2018 at "Kidney international"
DOI: 10.1016/j.kint.2018.01.025
Abstract: Pax genes encode developmental regulators that are expressed in a variety of tissues and control critical events in morphogenesis. In the kidney, Pax2 and Pax8 are expressed in embryonic development and in specific renal diseases… read more here.
Keywords: proteins potential; pax proteins; cancer; pax ... See more keywords
The effects of mixtures of potassium amyl xanthate (PAX) and isopropyl ethyl thionocarbamate (IPETC) collectors on grade and recovery in the froth flotation of a nickel sulfide ore
Sign Up to like & getrecommendations! Published in 2017 at "South African Journal of Chemical Engineering"
DOI: 10.1016/j.sajce.2017.07.001
Abstract: Abstract Potassium amyl xanthate (PAX) and sodium isobutyl xanthate (SIBX) are commonly used collectors in both the bulk and selective froth flotation of sulfide ores. These thiol xanthate collectors are conventionally mixed together as well… read more here.
Keywords: potassium amyl; amyl xanthate; xanthate; froth flotation ... See more keywords
Selisistat, a SIRT1 inhibitor, enhances paclitaxel activity in luminal and triple-negative breast cancer: in silico, in vitro, and in vivo studies
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2025.2458554
Abstract: Abstract Sirtuins (SIRTs) are NAD+-dependent histone deacetylases, which play a key role in cancer progression; however, their prognostic values in breast cancer (BC) remain a subject of debate and controversy. Accumulative evidence suggests that each… read more here.
Keywords: cancer; breast cancer; ex527 pax; pax ... See more keywords
Arthropod Pax Gene Evolution: A Role for Vanessa Cardui Twin of Eyeless in Eye Development
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msaf220
Abstract: Abstract Pax genes encode transcription factors involved in diverse processes. First identified in Drosophila, they have been found throughout the animal kingdom, suggesting highly conserved functions. Pax proteins are defined by a DNA-binding PRD domain… read more here.
Keywords: vanessa; vcar; arthropod pax; pax ... See more keywords
Xenorhabdus khoisanae SB10 produces Lys-rich PAX lipopeptides and a Xenocoumacin in its antimicrobial complex
Sign Up to like & getrecommendations! Published in 2019 at "BMC Microbiology"
DOI: 10.1186/s12866-019-1503-x
Abstract: BackgroundXenorhabdus spp. live in close symbiosis with nematodes of the Steinernema genus. Steinernema nematodes infect an insect larva and release their symbionts into the haemocoel of the insect. Once released into the haemocoel, the bacteria… read more here.
Keywords: lipopeptides xenocoumacin; pax lipopeptides; khoisanae sb10; xenorhabdus ... See more keywords
Chemical Synthesis of the PAX Protein Inhibitor EG1 and Its Ability to Slow the Growth of Human Colorectal Carcinoma Cells
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.709540
Abstract: Colorectal cancer is primarily a disease of the developed world. The incidence rate has continued to increase over time, reflecting both demographic and lifestyle changes, which have resulted in genomic and epigenomic modifications. Many of… read more here.
Keywords: growth; pax transcription; inhibitor eg1; cancer ... See more keywords