Diagnostic performance of PAX1 methylation as a biomarker for cervical lesions: a clinical study and meta-analysis
Sign Up to like & getrecommendations! Published in 2025 at "Annals of Medicine"
DOI: 10.1080/07853890.2025.2583319
Abstract: Abstract Objective To evaluate the diagnostic performance of PAX1 gene methylation in the detection of cervical lesions and assess its potential clinical application in cervical cancer screening through both a single-centre study and a meta-analysis.… read more here.
Keywords: methylation; meta analysis; cervical lesions; performance ... See more keywords
The application of PAX1 methylation detection and HPV E6/E7 mRNA detection in cervical cancer screening
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Obstetrics and Gynaecology Research"
DOI: 10.1111/jog.14869
Abstract: We aimed to explore the application of PAX1 methylation and human papillomavirus (HPV) E6/E7 mRNA detection in cervical cancer screening and to compare the efficacy with high‐risk (HR)‐HPV detection. read more here.
Keywords: application pax1; detection; hpv mrna; pax1 methylation ... See more keywords
Evaluating PAX1 methylation for cervical cancer screening triage in non-16/18 hrHPV-positive women
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DOI: 10.1186/s12885-024-12696-7
Abstract: In China, the national cervical cancer screening protocol involves initial testing for high-risk human papillomavirus (hrHPV), followed by cytology for hrHPV-positive cases. This study evaluates the effectiveness of PAX1 methylation (PAX1m) analysis in identifying precancerous… read more here.
Keywords: hrhpv positive; non hrhpv; pax1m; cytology ... See more keywords
The role of PAX1 methylation in predicting the pathological upgrade of cervical intraepithelial neoplasia before cold knife conization
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1064722
Abstract: Objective To explore the ability of PAX1 methylation (PAX1m) to predict the pathological upgrade of cervical intraepithelial neoplasia (CIN) before cold knife conization (CKC). Methods A total of 218 women that underwent colposcopy-directed biopsy (CDB)… read more here.
Keywords: pax1 methylation; pathology; predicting pathological; ckc ... See more keywords
Detection of CADM1, MAL, and PAX1 Methylation by ddPCR for Triage of HPV-Positive Cervical Lesions
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DOI: 10.3390/biomedicines13061450
Abstract: The aberrant DNA methylation of tumour suppressor genes, including CADM1, MAL, and PAX1, is implicated in cervical carcinogenesis. Objectives: This pilot study aimed to evaluate the methylation levels of these genes in HPV-positive women and… read more here.
Keywords: methylation; ddpcr; hpv positive; mal pax1 ... See more keywords
Association and Effectiveness of PAX1 Methylation and HPV Viral Load for the Detection of Cervical High-Grade Squamous Intraepithelial Lesion
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DOI: 10.3390/pathogens12010063
Abstract: Background: PAX1 methylation (PAX1m) and HPV viral load (VL) have been reported to detect cervical high-grade squamous intraepithelial lesions (HSIL), but the relationship between them is unclear. This study aimed to evaluate the correlation between… read more here.
Keywords: pax1 methylation; hpv viral; cervical high; viral load ... See more keywords