CP‐31398 inhibits the progression of cervical cancer through reversing the epithelial mesenchymal transition via the downregulation of PAX2s
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27109
Abstract: CP‐31398, a styrylquinazoline, emerges from a screen for therapeutic agents that restore the wild‐type DNA‐binding conformation of mutant p53 to suppress tumors in vivo, but its effects on cervical cancer (CC) remain unknown. Hence, this… read more here.
Keywords: mesenchymal transition; cervical cancer; epithelial mesenchymal; pax2 ... See more keywords
PAX2 is dispensable for in vitro nephron formation from human induced pluripotent stem cells
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-04813-3
Abstract: The kidney is formed by reciprocal interactions between the nephron progenitor and the ureteric bud, the former of which gives rise to the epithelia of nephrons consisting of glomeruli and renal tubules. The transcription factor… read more here.
Keywords: human induced; nephron progenitors; pluripotent stem; induced pluripotent ... See more keywords
Immunohistochemical expression of PAX8, PAX2, and cytokeratin in melanomas
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cutaneous Pathology"
DOI: 10.1111/cup.14041
Abstract: Deviations from the classic melanocytic immunophenotype in melanoma can present a diagnostic challenge. PAX8 and PAX2 are common markers for renal or Müllerian differentiation. While most PAX8+ or PAX2+ carcinomas are seldom confused with melanoma,… read more here.
Keywords: pax8 pax2; expression; pax2 cytokeratin; pax2 ... See more keywords
Detection of De Novo PAX2 Variants and Phenotypes in Chinese Population: A Single-Center Study
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.799562
Abstract: Background: PAX2 is a nuclear transcription factor gene that is highly conserved among species. Variants within PAX2 could result in optic nerve colobomas and kidney hypoplasia. However, little clinical and genetic information is currently available… read more here.
Keywords: single center; kidney; chinese population; pax2 variants ... See more keywords
PAX2 promotes epithelial ovarian cancer progression involving fatty acid metabolic reprogramming
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Oncology"
DOI: 10.3892/ijo.2020.4958
Abstract: Ovarian cancer is the fifth most common type of cancer afflicting women and frequently presents at a late stage with a poor prognosis. While paired box 2 (PAX2) expression is frequently lost in high-grade serous… read more here.
Keywords: fatty acid; expression; ovarian cancer; cancer ... See more keywords
Chromatin topology defines estradiol-primed progesterone receptor and PAX2 binding in endometrial cancer cells
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.66034
Abstract: Estrogen (E2) and Progesterone (Pg), via their specific receptors (ERalpha and PR), are major determinants in the development and progression of endometrial carcinomas, However, their precise mechanism of action and the role of other transcription… read more here.
Keywords: topology; endometrial cancer; pax2 binding; pax2 ... See more keywords