Functional non-coding polymorphism in an EPHA2 promoter PAX2 binding site modifies expression and alters the MAPK and AKT pathways
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DOI: 10.1038/s41598-017-10117-3
Abstract: To identify possible genetic variants influencing expression of EPHA2 (Ephrin-receptor Type-A2), a tyrosine kinase receptor that has been shown to be important for lens development and to contribute to both congenital and age related cataract… read more here.
Keywords: pax2 binding; binding site; mapk akt; epha2 promoter ... See more keywords
Chromatin topology defines estradiol-primed progesterone receptor and PAX2 binding in endometrial cancer cells
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DOI: 10.7554/elife.66034
Abstract: Estrogen (E2) and Progesterone (Pg), via their specific receptors (ERalpha and PR), are major determinants in the development and progression of endometrial carcinomas, However, their precise mechanism of action and the role of other transcription… read more here.
Keywords: topology; endometrial cancer; pax2 binding; pax2 ... See more keywords