Dentithecamides A-H, Diacylated Zoanthoxanthin Derivatives with PAX3-FOXO1 Inhibitory Activity from the Hydroid Dentitheca habereri.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.2c00246
Abstract: Chemical investigation of the marine hydroid Dentitheca habereri led to the identification of eight new diacylated zoanthoxanthin alkaloids, named dentithecamides A-H (1-8), along with three previously reported analogues, zoamides B-D (9-11). The structures of compounds… read more here.
Keywords: dentitheca habereri; hydroid dentitheca; diacylated zoanthoxanthin; pax3 foxo1 ... See more keywords
Immunohistochemical detection of PAX-FOXO1 fusion proteins in alveolar rhabdomyosarcoma using breakpoint specific monoclonal antibodies
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DOI: 10.1038/s41379-020-00719-0
Abstract: Alveolar Rhabdomyosarcoma (ARMS) is an aggressive pediatric cancer with about 80% of cases characterized by either a t(1;13)(p36;q14) or t(2;13)(q35;q14), which results in the formation of the fusion oncogenes PAX7-FOXO1 and PAX3-FOXO1, respectively. Since patients… read more here.
Keywords: detection; foxo1; rhabdomyosarcoma; fusion ... See more keywords
Reduced B7-H3 expression by PAX3-FOXO1 knockdown inhibits cellular motility and promotes myogenic differentiation in alveolar rhabdomyosarcoma
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DOI: 10.1038/s41598-021-98322-z
Abstract: B7-H3 (also known as CD276) is associated with aggressive characteristics in various cancers. Meanwhile, in alveolar rhabdomyosarcoma (ARMS), PAX3-FOXO1 fusion protein is associated with increased aggressiveness and poor prognosis. In the present study, we explored… read more here.
Keywords: myogenic differentiation; expression; pax3 foxo1; pax3 ... See more keywords
PAX3-FOXO1 escapes miR-495 regulation during muscle differentiation
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DOI: 10.1080/15476286.2018.1564464
Abstract: ABSTRACT Pax3 plays an essential role in myogenesis. Previously, we found a tumor-signature chimeric fusion RNA, PAX3-FOXO1 also present during muscle differentiation, raising the possibility of its physiological role. Here we demonstrated that the fusion… read more here.
Keywords: fusion; muscle differentiation; pax3 foxo1; pax3 ... See more keywords
Abstract 4630: Characterizing oncogene addiction in alveolar rhabdomyosarcoma reveals novel strategies for combination therapy
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DOI: 10.1158/1538-7445.am2018-4630
Abstract: Rhabdomyosarcoma is the most common soft tissue sarcoma in children. The aggressive alveolar subtype (aRMS) is characterized by chromosomal translocations, most often a t(2;13) resulting in the expression of the oncogenic fusion protein PAX3-FOXO1 which… read more here.
Keywords: protein; combination; rhabdomyosarcoma; combination therapy ... See more keywords
Abstract 5867: Identification of novel inhibitors of the PAX3-FOXO1 oncogenic driver in rhabdomyosarcoma
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DOI: 10.1158/1538-7445.am2018-5867
Abstract: Background: Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood, representing 8% of all childhood tumors. The most aggressive subtype of RMS is associated with chromosomal translocations creating a fusion transcription factor, most… read more here.
Keywords: rhabdomyosarcoma; pax3 foxo1; foxo1 oncogenic; oncogenic driver ... See more keywords
Abstract 3533: Zebrafish her3 knockout impacts developmental and rhabdomyosarcoma-related gene signatures
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DOI: 10.1158/1538-7445.am2023-3533
Abstract: HES3 is a basic helix-loop-helix transcription factor that regulates neural stem cell renewal during development. HES3 overexpression is predictive of reduced overall survival in patients with fusion-positive rhabdomyosarcoma, a pediatric cancer that resembles immature and… read more here.
Keywords: pax3 foxo1; hes3; her3; rhabdomyosarcoma ... See more keywords
Regulatory landscape fusion in rhabdomyosarcoma through interactions between the PAX3 promoter and FOXO1 regulatory elements
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DOI: 10.1186/s13059-017-1225-z
Abstract: BackgroundThe organisation of vertebrate genomes into topologically associating domains (TADs) is believed to facilitate the regulation of the genes located within them. A remaining question is whether TAD organisation is achieved through the interactions of… read more here.
Keywords: pax3 promoter; landscape; rhabdomyosarcoma; pax3 foxo1 ... See more keywords