A patient with B-cell acute lymphoblastic leukemia with PAX5-ETV6 rearrangement with dic(9;12)(p13;p13) identified by chromosomal microarray
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Hematology"
DOI: 10.1007/s00277-018-3291-z
Abstract: Dear Editor, The identification of recurrent gene rearrangements in the clinical laboratory is important for a precise diagnosis and treatment decisions in patients with acute leukemia [1]. Currently, cytogenetic tests and reverse transcription-PCR (RT-PCR) are… read more here.
Keywords: pax5; pax5 etv6; p13; fusion ... See more keywords
Co-Localization and Interaction of Pax5 with Iba1 in Brain of Mice
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DOI: 10.1007/s10571-017-0566-1
Abstract: The Pax5, a B-cell-Specific Activator Protein (BSAP) and redox-sensitive transcription factor, is expressed in the immune-privileged brain, B-lymphocytes, lymph nodes and spleen. PAX5-mediated immune pathway has also been described in the progression of Glioblastoma multiforme.… read more here.
Keywords: pax5 iba1; pax5; brain mice; interaction ... See more keywords
Functional analysis of a novel fusion protein PAX5-KIDINS220 identified in a pediatric Ph-like ALL patient
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DOI: 10.1007/s12185-020-02944-4
Abstract: PAX5-KIDINS220 (PAX5-K220) is a novel chimeric fusion gene identified in a pediatric Philadelphia chromosome (Ph)-like acute lymphoblastic leukemia (ALL) patient, but the function of the encoded fusion protein has not yet been analyzed. Here, we… read more here.
Keywords: pax5 k220; pax5; fusion; fusion protein ... See more keywords
Trajectories from single-cells to PAX5-driven leukemia reveal PAX5-MYC interplay in vivo
Sign Up to like & getrecommendations! Published in 2025 at "Leukemia"
DOI: 10.1038/s41375-025-02626-2
Abstract: PAX5 acts as a master regulator of B-cell proliferation and differentiation. Its germline and somatic deregulation have both been implicated in the development of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). However, the process how reduced… read more here.
Keywords: bcp; pax5; trajectories single; pre leukemic ... See more keywords
PAX5 fusion genes in acute lymphoblastic leukemia: A literature review
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DOI: 10.1097/md.0000000000033836
Abstract: Acute lymphoblastic leukemia (ALL) is a common cancer affecting children worldwide. The development of ALL is driven by several genes, some of which can be targeted for treatment by inhibiting gene fusions. PAX5 is frequently… read more here.
Keywords: pax5; acute lymphoblastic; pax5 fusion; lymphoblastic leukemia ... See more keywords
PAX5 and circ1857 affected DLBCL progression and B-cell proliferation through regulating GINS1.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer science"
DOI: 10.1111/cas.15856
Abstract: PAX5, a member of the paired box gene family of transcription factors, is a B-cell-specific activator protein that plays important roles during B lymphopoiesis. Two putative PAX5 binding sites in the human GINS1 promoter region… read more here.
Keywords: gins1; dlbcl progression; pax5; expression ... See more keywords
Evaluation of Pax5 expression and comparison with BLA.36 and CD79&agr;cy in feline non‐Hodgkin lymphoma
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DOI: 10.1111/vco.12262
Abstract: Paired box gene 5 (Pax5) is a widely used B-cell marker for human and canine non-Hodgkin's lymphoma (nHL); however, in the literature there is only one case report using Pax5 in a cat B-cell lymphoma.… read more here.
Keywords: hodgkin lymphoma; pax5; non hodgkin; expression ... See more keywords
Paired Box 5 (PAX5) Gene Has Diagnostic and Prognostic Potential in Nasopharyngeal Carcinoma
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DOI: 10.2147/ijgm.s442835
Abstract: Purpose Paired Box 5 (PAX5) is a transcription factor that is widely associated with carcinogenesis. PAX5 can maintain Epstein-Barr virus (EBV) latency in B cells, while a close association exists between EBV infection and nasopharyngeal… read more here.
Keywords: pax5; paired box; box pax5; nasopharyngeal carcinoma ... See more keywords
PAX5 alterations in B-cell acute lymphoblastic leukemia
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DOI: 10.3389/fonc.2022.1023606
Abstract: PAX5, a master regulator of B cell development and maintenance, is one of the most common targets of genetic alterations in B-cell acute lymphoblastic leukemia (B-ALL). PAX5 alterations consist of copy number variations (whole gene,… read more here.
Keywords: pax5; leukemia; pax5 alterations; alterations cell ... See more keywords
Case report: A familial B-acute lymphoblastic leukemia associated with a new germline pathogenic variant in PAX5. The first report in Mexico
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2024.1355335
Abstract: B-cell acute lymphoblastic leukemia (B-ALL) is one of the most common childhood cancers worldwide. Although most cases are sporadic, some familial forms, inherited as autosomal dominant traits with incomplete penetrance, have been described over the… read more here.
Keywords: report; history; variant; pax5 ... See more keywords
Pax5 Negatively Regulates Osteoclastogenesis through Downregulation of Blimp1
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DOI: 10.3390/ijms22042097
Abstract: Paired box protein 5 (Pax5) is a crucial transcription factor responsible for B-cell lineage specification and commitment. In this study, we identified a negative role of Pax5 in osteoclastogenesis. The expression of Pax5 was time-dependently… read more here.
Keywords: lineage; pax5; bone; blimp1 ... See more keywords