PAX5 fusion genes in acute lymphoblastic leukemia: A literature review
Sign Up to like & getrecommendations! Published in 2023 at "Medicine"
DOI: 10.1097/md.0000000000033836
Abstract: Acute lymphoblastic leukemia (ALL) is a common cancer affecting children worldwide. The development of ALL is driven by several genes, some of which can be targeted for treatment by inhibiting gene fusions. PAX5 is frequently… read more here.
Keywords: pax5; acute lymphoblastic; pax5 fusion; lymphoblastic leukemia ... See more keywords
PAX5 fusion genes are frequent in poor risk childhood acute lymphoblastic leukaemia and can be targeted with BIBF1120
Sign Up to like & getrecommendations! Published in 2022 at "eBioMedicine"
DOI: 10.2139/ssrn.4045959
Abstract: Summary Background Despite intensive risk-based treatment protocols, 15% of paediatric patients with B-Cell Precursor Acute Lymphoblastic Leukaemia (BCP-ALL) experience relapse. There is urgent need of novel strategies to target poor prognosis subgroups, like PAX5 translocated.… read more here.
Keywords: fusion genes; leukaemia; pax5 fusion; risk ... See more keywords