Silencing of long noncoding RNA LINC00958 prevents tumor initiation of pancreatic cancer by acting as a sponge of microRNA-330-5p to down-regulate PAX8.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.12.017
Abstract: Pancreatic cancer (PC) represents a relatively rare but severe malignancy worldwide. Accumulated studies have emphasized the potential of long noncoding RNA (lncRNA) as therapeutic strategies for several human cancers. Thus, we aimed to investigate whether… read more here.
Keywords: pax8; rna; linc00958; cancer ... See more keywords
Mayer-Rokitansky-Künster-Hauser syndrome due to 2q12.1q14.1 deletion: PAX8 the causing gene?
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medical genetics"
DOI: 10.1016/j.ejmg.2019.103812
Abstract: Mayer-Rokitansky-Küster-Hauser syndrome (MRKH) is a rare malformative disorder, characterized by congenital aplasia of the uterus and the upper two thirds of the vagina (MIM #277000). For a majority of patients, the disorder remained without identified… read more here.
Keywords: pax8; 2q12 1q14; hauser syndrome; mayer rokitansky ... See more keywords
PAX8 positivity in nested variant of UROTHELIAL carcinoma: a potential diagnostic pitfall.
Sign Up to like & getrecommendations! Published in 2019 at "Human pathology"
DOI: 10.1016/j.humpath.2019.09.012
Abstract: Nested variant of urothelial carcinoma is a rare variant of urothelial carcinoma morphologically characterized by infiltrative nests of cytologically bland urothelial cells. It is widely recognized that nested variant of urothelial carcinoma can closely mimic… read more here.
Keywords: pax8; positivity; variant urothelial; nested variant ... See more keywords
PAX8 activates a p53-p21-dependent pro-proliferative effect in high grade serous ovarian carcinoma
Sign Up to like & getrecommendations! Published in 2018 at "Oncogene"
DOI: 10.1038/s41388-017-0040-z
Abstract: High grade serous carcinoma (HGSC) is the most common subtype of ovarian cancer and it is now widely accepted that this disease often originates from the fallopian tube epithelium. PAX8 is a fallopian tube lineage… read more here.
Keywords: pax8; grade serous; fallopian tube; high grade ... See more keywords
PAX8 activates metabolic genes via enhancer elements in Renal Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-11672-1
Abstract: Transcription factor networks shape the gene expression programs responsible for normal cell identity and pathogenic state. Using Core Regulatory Circuitry analysis (CRC), we identify PAX8 as a candidate oncogene in Renal Cell Carcinoma (RCC) cells.… read more here.
Keywords: renal cell; pax8; cell carcinoma; enhancer elements ... See more keywords
0608 PAX8/PAX8-AS1 DNA methylation levels are not associated with sleep duration in medicated patients with unexplained hypersomnolence
Sign Up to like & getrecommendations! Published in 2023 at "SLEEP"
DOI: 10.1093/sleep/zsad077.0608
Abstract: The biological basis of daytime sleepiness and excessive sleep duration in patients with unexplained hypersomnolence is unknown. However, a growing body of evidence suggests modulations in the epigenome coincide with objective measures of sleep, suggesting… read more here.
Keywords: pax8; pax8 pax8; dna methylation; pax8 as1 ... See more keywords
Significance analysis of PAX8 expression in endometrial carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000031159
Abstract: To analyze the expression and prognostic value of paired-box 8 (PAX8) expression in uterine corpus endometrial carcinoma (UCEC) by bioinformatics. The expression of PAX8 gene in UCEC was analyzed by R language and immunohistochemistry. The… read more here.
Keywords: endometrial carcinoma; expression pax8; pax8; expression ... See more keywords
Adipose‐derived mesenchymal stem cells induced PAX8 promotes ovarian cancer cell growth by stabilizing TAZ protein
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16511
Abstract: Our previous studies have shown that the Adipose‐derived mesenchymal stem cells (ADSCs) can regulate metastasis and development of ovarian cancer. However, its specific mechanism has yet to be fully revealed. In this study, an RNA‐seq… read more here.
Keywords: pax8; ovarian cancer; cancer cell; cancer ... See more keywords
The transcription factor PAX8 promotes angiogenesis in ovarian cancer through interaction with SOX17
Sign Up to like & getrecommendations! Published in 2022 at "Science Signaling"
DOI: 10.1126/scisignal.abm2496
Abstract: PAX8 is a master transcription factor that is essential during embryogenesis and promotes neoplastic growth. It is expressed by the secretory cells lining the female reproductive tract, and its deletion during development results in atresia… read more here.
Keywords: pax8; transcription; ovarian cancer; transcription factor ... See more keywords
A combination of immunohistochemical markers, MUC1, MUC5AC, PAX8 and growth pattern for characterization of mucinous neoplasm of the ovary
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Gynecological Cancer"
DOI: 10.1136/ijgc-2021-003104
Abstract: Objective Because mucinous carcinomas are rare tumors that affect several organ sites and are known to originate from different tissues, leading to frequent misdiagnoses, the objective was to characterize the differences between primary mucinous tumors… read more here.
Keywords: pax8; muc1 muc5ac; growth pattern; mucinous ovarian ... See more keywords
Abstract KP02: STARING DOWN THE BARREL OF A TUBE AT THE ORIGINS OF OVARIAN CANCER
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Cancer Research"
DOI: 10.1158/1557-3265.ovcasymp16-kp02
Abstract: There is an emerging consensus that a majority of high-grade serous carcinomas, the most common type of ovarian cancer, are derived from PAX8-expressing cells in the distal fallopian tube. Careful histologic examination of fallopian tubes… read more here.
Keywords: pax8; grade serous; tube; high grade ... See more keywords