Nephron-specific deletion of ALMS1 (Alstrom syndrome 1) increases surface NKCC2 expression and NaCl reabsorption in the Thick Ascending Limb
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DOI: 10.1152/physiol.2023.38.s1.5731922
Abstract: Mutations in the ALMS1 gene in humans cause Alström syndrome, characterized by progressive metabolic alterations that include obesity, hypertension, and chronic kidney disease (CKD). SNPs in the ALMS1 gene in the general population are associated… read more here.
Keywords: deletion; pax8 alms1; expression; physiology ... See more keywords