A comparative analysis of paxillin and Hic‐5 proximity interactomes
Sign Up to like & getrecommendations! Published in 2024 at "Cytoskeleton"
DOI: 10.1002/cm.21878
Abstract: Focal adhesions serve as structural and signaling hubs, facilitating bidirectional communication at the cell–extracellular matrix interface. Paxillin and the related Hic‐5 (TGFβ1i1) are adaptor/scaffold proteins that recruit numerous structural and regulatory proteins to focal adhesions,… read more here.
Keywords: paxillin; focal adhesions; hic paxillin; paxillin hic ... See more keywords
Paxillin regulated genomic networks in prostate cancer
Sign Up to like & getrecommendations! Published in 2019 at "Steroids"
DOI: 10.1016/j.steroids.2019.108463
Abstract: Paxillin is extensively involved in focal adhesion signaling and kinase signaling throughout the plasma membrane and cytoplasm. However, recent studies in prostate cancer suggest that paxillin also plays a critical role in regulating gene expression… read more here.
Keywords: androgen; paxillin regulated; paxillin; prostate cancer ... See more keywords
Paxillin regulates androgen receptor expression associated with granulosa cell focal adhesions
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Human Reproduction"
DOI: 10.1093/molehr/gaae018
Abstract: Abstract Paxillin is a ubiquitously expressed adaptor protein integral to focal adhesions, cell motility, and apoptosis. Paxillin has also recently been implicated as a mediator of nongenomic androgen receptor (AR) signaling in prostate cancer and… read more here.
Keywords: paxillin; paxillin knockout; focal adhesions; androgen receptor ... See more keywords
Conformational dynamics and multimodal interaction of Paxillin with the focal adhesion targeting domain
Sign Up to like & getrecommendations! Published in 2025 at "Science Advances"
DOI: 10.1126/sciadv.adt9936
Abstract: Paxillin (PXN) and focal adhesion kinase (FAK) are two major components of the focal adhesion complex, a multiprotein structure linking the intracellular cytoskeleton to the cell exterior. The interaction between the disordered amino-terminal domain of… read more here.
Keywords: focal adhesion; paxillin; targeting domain; adhesion ... See more keywords
Identification of Paxillin as a Prognostic Factor for Glioblastoma via Integrated Bioinformatics Analysis
Sign Up to like & getrecommendations! Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/7171126
Abstract: Glioblastoma (GBM) is the most prevalent and aggressive type of brain tumor in the central nervous system. Clinical outcomes for patients with GBM are unsatisfactory. Here, we aimed to identify novel, reliable prognostic factors for… read more here.
Keywords: glioblastoma; factor; analysis; gbm ... See more keywords
Investigation of Tight Junction Protein Alterations in ADHD: The Role of Claudin-5, β-Catenin and Paxillin.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of attention disorders"
DOI: 10.1177/10870547251400398
Abstract: OBJECTIVE Blood-brain barrier permeability (BBB) has been suggested to be involved in the etiopathogenesis of ADHD. Claudin-5, β-catenin and paxillin are important molecules with different roles in this barrier. Alterations in these molecules may disrupt… read more here.
Keywords: paxillin; role; catenin; catenin paxillin ... See more keywords
Hesperetin Inhibits TGF-β1-Induced Migration and Invasion of Triple Negative Breast Cancer MDA-MB-231 Cells via Suppressing Fyn/Paxillin/RhoA Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Integrative Cancer Therapies"
DOI: 10.1177/15347354221086900
Abstract: Triple-negative breast cancer is an aggressive subtype of breast cancer with poor clinical outcomes and poor prognosis. Hesperetin is an active component extracted from Citrus fruits and Traditional Chinese Medicine has a wide range of… read more here.
Keywords: paxillin; breast cancer; mda 231; 231 cells ... See more keywords
Phosphorylated paxillin and phosphorylated FAK constitute subregions within focal adhesions.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cell science"
DOI: 10.1242/jcs.258764
Abstract: Integrin-mediated adhesions are convergence points of multiple signaling pathways. Their inner structure and their diverse functions can be studied with super-resolution microscopy. Here, we examined the spatial organization within focal adhesion by analyzing several adhesion… read more here.
Keywords: focal adhesions; paxillin; within focal; microscopy ... See more keywords
Down-regulated paxillin suppresses cell proliferation and invasion by inhibiting M2 macrophage polarization in colon cancer
Sign Up to like & getrecommendations! Published in 2018 at "Biological Chemistry"
DOI: 10.1515/hsz-2018-0002
Abstract: Abstract The paxillin and M2 macrophage are all involved in cell proliferation and tumor progression, and this study aims to explore the interaction between them in colon cancer and the role of paxillin in cancer… read more here.
Keywords: macrophage polarization; colon cancer; macrophage; cancer ... See more keywords
Regulation of paxillin-p130-PI3K-AKT signaling axis by Src and PTPRT impacts colon tumorigenesis
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.10654
Abstract: Protein tyrosine phosphatase receptor T (PTPRT) is frequently mutated in a variety of human cancers including colorectal cancer. Here we report that PTPRT knockout increases the size of mouse colon tumors in the Apcmin+/− genetic… read more here.
Keywords: paxillin; ptprt; kinase; src ... See more keywords
Endosomal sorting and c-Cbl targeting of paxillin to autophagosomes regulate cell-matrix adhesion turnover in human breast cancer cells
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.16105
Abstract: Post-translational mechanisms regulating cell-matrix adhesion turnover during cell locomotion are not fully elucidated. In this study, we uncovered an essential role of Y118 site-specific tyrosine phosphorylation of paxillin, an adapter protein of focal adhesion complexes,… read more here.
Keywords: turnover; adhesion; breast cancer; cancer cells ... See more keywords