Abstract A124: CBB-120: A TROP2-targeted dual-payload ADC combining Top1i and ATRi mechanisms demonstrates superior efficacy in preclinical models and improved safety in non-human primates
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DOI: 10.1158/1535-7163.targ-25-a124
Abstract: Antibody-drug conjugates (ADCs) have emerged as a powerful strategy for treating TROP2-expressing epithelial cancers, including breast and lung cancers. Among current therapies, Trodelvy® and Datroway® (Dato-DXd) carrying topoisomerase I inhibitors (Top1i) have demonstrated notable clinical… read more here.
Keywords: cbb 120; payload adc; trop2; top1i atri ... See more keywords
Abstract 7334: Targeting Nectin-4 with a first-in-class triple MMAE/dual TOP1i payload ADC showing synergistic and durable activity across all target expression levels and favorable tolerability
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DOI: 10.1158/1538-7445.am2025-7334
Abstract: The Araris’ site-specific and one-step linker conjugation technology aims at generating stable, safe and highly potent ADCs without the need for antibody engineering prior to payload conjugation. We here present a novel Nectin-4 targeting triple-warhead… read more here.
Keywords: first class; payload adc; target; payload ... See more keywords