Molecular dynamics and binding selectivity of nucleotides and polynucleotide substrates with EIF2C2/Ago2 PAZ domain.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2017.10.145
Abstract: RNA interference (RNAi) constitutes a major target in drug discovery. Recently, we reported that the Argonaute protein 2 (Ago2) PAZ domain selectively binds with all ribonucleotides except adenine and poorly recognizes deoxyribonucleotides. The binding properties… read more here.
Keywords: ago2 paz; molecular dynamics; paz domain; domain ... See more keywords
PAZ domain is critical for spermatogenesis in chicken.
Sign Up to like & getrecommendations! Published in 2021 at "Animal biotechnology"
DOI: 10.1080/10495398.2021.2011742
Abstract: Piwi-like protein 1 (PIWIL1) plays a crucial role in stem cell proliferation, embryogenesis, growth, and development. We aimed to unravel the function of PIWIL1 and its Piwi/Argonaute/Zwille (PAZ) domain in chicken embryogenesis. The expression of… read more here.
Keywords: critical spermatogenesis; paz domain; domain critical; paz ... See more keywords