Identification of a novel small-molecule compound targeting the influenza A virus polymerase PB1-PB2 interface
Sign Up to like & getrecommendations! Published in 2017 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2016.11.005
Abstract: &NA; The PB1 C‐terminal domain and PB2 N‐terminal domain interaction of the influenza A polymerase, which modulates the assembly of PB1 and PB2 subunits, may serve as a valuable target for the development of novel… read more here.
Keywords: small molecule; pb1 pb2; polymerase; novel small ... See more keywords
Joint action of Pb1 and Pb2 provide dominant complementary resistance against new races of Peronospora belbahrii (Basil Downy Mildew).
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DOI: 10.1094/phyto-02-21-0065-r
Abstract: Sweet basil (Ocimum basilicum, 2n=4x=48) is susceptible to downy mildew caused by Peronospora belbahrii. Pb1 gene exhibit complete resistance to the disease. However, Pb1 became prone to disease due to occurrence of a new virulent… read more here.
Keywords: downy mildew; basil; pb1; resistance ... See more keywords
Nucleoporin 85 interacts with influenza A virus PB1 and PB2 to promote its replication by facilitating nuclear import of ribonucleoprotein
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.895779
Abstract: Transcription and replication of the influenza A virus (IAV) genome take place in the nucleus of infected cells, which rely on host factors to aid viral ribonucleoprotein (vRNP) to cross the nuclear pore complex (NPC)… read more here.
Keywords: replication; pb1 pb2; nuclear import; pb2 ... See more keywords