PBB3 binding in a patient with corticobasal syndrome
Sign Up to like & getrecommendations! Published in 2018 at "Movement Disorders"
DOI: 10.1002/mds.27405
Abstract: Corticobasal degeneration (CBD) is a rapidly progressive parkinsonism typically associated with highly asymmetric cortical signs including apraxia, language impairment, cortical sensory deficit, and myoclonus. Pathologically there are straight filaments of tau associated with ballooned neurons… read more here.
Keywords: pet; tau; pbb3 binding; corticobasal syndrome ... See more keywords
[11C]PBB3 binding in Aβ(–) or Aβ(+) corticobasal syndrome
Sign Up to like & getrecommendations! Published in 2023 at "Synapse"
DOI: 10.1002/syn.22269
Abstract: Corticobasal syndrome (CBS) is associated with 4‐repeat tauopathy and/or Alzheimer's disease pathologies. To examine tau and amyloid‐β (Aβ) deposits in CBS patients using positron emission tomography (PET). Eight CBS patients and three healthy individuals lacking… read more here.
Keywords: pbb3 binding; pbb3; cbs patients; corticobasal syndrome ... See more keywords
Identification and in vitro characterization of C05-01, a PBB3 derivative with improved affinity for alpha-synuclein
Sign Up to like & getrecommendations! Published in 2020 at "Brain Research"
DOI: 10.1016/j.brainres.2020.147131
Abstract: Abstract The neuropathological hallmark of Parkinsons disease, multiple system atrophy and dementia with Lewy bodies is the accumulation of α-synuclein. The development of an imaging biomarker for α-synuclein is an unmet need. To date, no… read more here.
Keywords: synuclein; pathology; improved affinity; c05 ... See more keywords