PBI-4050, A NOVEL FIRST-IN-CLASS AGENT, REDUCES PULMONARY HYPERTENSION, LUNG REMODELING AND RIGHT VENTRICULAR DYSFUNCTION IN HEART FAILURE
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DOI: 10.1016/s0735-1097(18)31207-5
Abstract: Heart failure with reduced ejection fraction (HFrEF) causes lung remodeling characterized by myofibroblasts proliferation and fibrosis leading to a restrictive lung syndrome with pulmonary hypertension (PH) and right ventricular (RV) dysfunction. PBI-4050 is a first-in-class… read more here.
Keywords: pulmonary hypertension; right ventricular; heart failure; lung remodeling ... See more keywords