PDZ Binding Kinase/T-LAK Cell-Derived Protein Kinase Plays an Oncogenic Role and Promotes Immune Escape in Human Tumors
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DOI: 10.1155/2021/8892479
Abstract: Background PDZ binding kinase (PBK)/T-LAK cell-derived protein kinase (TOPK) is an important mitotic kinase that promotes tumor progression in some cancers. However, the pan-cancer analysis of PBK/TOPK and its role in tumor immunity are limited.… read more here.
Keywords: kinase; role; pdz binding; pbk ... See more keywords
PDZ Binding Kinase (PBK) - a Novel Gene Driving Genomic Evolution in Multiple Myeloma
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DOI: 10.1182/blood-2018-99-119186
Abstract: As in all cancers, genomic instability leads to ongoing acquisition of new genetic changes in multiple myeloma (MM). This adaptability underlies the development of drug resistance and progression in MM. This genomic instability is driven… read more here.
Keywords: genomic instability; multiple myeloma; expression; pbk ... See more keywords
Enhanced Expression of the Key Mitosis Regulator Cyclin B1 Is Mediated by PDZ-Binding Kinase in Islets of Pregnant Mice
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the Endocrine Society"
DOI: 10.1210/js.2017-00338
Abstract: Abstract The proliferation of pancreatic β cells is enhanced to enable an increase in β-cell mass and to compensate for insulin resistance during pregnancy. To elucidate the mechanisms involved, we previously investigated islets from pregnant… read more here.
Keywords: binding kinase; kinase; expression; pdz binding ... See more keywords
PBK Enhances Cellular Proliferation With Histone H3 Phosphorylation and Suppresses Migration and Invasion With CDH1 Stabilization in Colorectal Cancer
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DOI: 10.3389/fphar.2021.772926
Abstract: Colorectal cancer (CRC) is one of the most frequent gastrointestinal malignancies with high morbidity and mortality rates. Several biological markers for the prognostication of patient outcome of CRCs are available. Recently, our group identified two… read more here.
Keywords: migration invasion; pbk; cellular proliferation; crc cells ... See more keywords
Identification of PBK as a hub gene and potential therapeutic target for medulloblastoma
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DOI: 10.3892/or.2022.8336
Abstract: Medulloblastoma (MB) is the most frequent malignant brain tumor in pediatrics. Since the current standard of care for MB consisting of surgery, cranio-spinal irradiation and chemotherapy often leads to a high morbidity rate, a number… read more here.
Keywords: pbk; potential therapeutic; expression; hub gene ... See more keywords