PBK/TOPK inhibitor OTS964 resistance is mediated by ABCB1-dependent transport function in cancer: in vitro and in vivo study
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Cancer"
DOI: 10.1186/s12943-022-01512-0
Abstract: ABCB1 overexpression significantly desensitized both drug-selected and gene-transfected cells, which overexpress ABCB1, to OTS964 and that this drug resistance can be antagonized by verapamil, a known ABCB1 inhibitor. Consistently, a similar trend was observed in… read more here.
Keywords: cancer; pbk topk; resistance; inhibitor ... See more keywords
Gossypetin Inhibits Solar-UV Induced Cutaneous Basal Cell Carcinoma Through Direct Inhibiting PBK/TOPK Protein Kinase.
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DOI: 10.2174/1871520619666190301123131
Abstract: Skin photoaging, skin inflammation and skin cancer are related with excessive exposure to solar ultraviolet light (solar-UV). PDZ-binding kinase/T-LAK cell-originated protein kinase (PBK/TOPK), a member of the serine/threonine protein kinase, which regulates the signaling cascades… read more here.
Keywords: kinase; solar induced; topk; phosphor ... See more keywords
PBK/TOPK Is a Favorable Prognostic Biomarker Correlated with Antitumor Immunity in Colon Cancers
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10020299
Abstract: Immune checkpoint inhibitor therapy has proven efficacy in a subset of colon cancer patients featuring a deficient DNA mismatch repair system or a high microsatellite instability profile. However, there is high demand for more effective… read more here.
Keywords: colon cancer; pbk topk; colon; expression ... See more keywords