Treatment of hepatitis C virus infection with direct-acting antivirals plus ribavirin eliminates viral RNA from peripheral blood mononuclear cells and reduces virologic relapse in diverse hepatic parenchymal changes.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of virology"
DOI: 10.1007/s00705-021-04969-4
Abstract: Elimination of hepatitis C virus (HCV) may fail, leading to a non-response outcome because of inappropriate testing for viral RNA in peripheral blood mononuclear cells (PBMCs). Sequelae of HCV genotype 4 therapy with sofosbuvir and… read more here.
Keywords: pbmcs; treatment; hcv; relapse ... See more keywords
Detection of hepatitis C virus (HCV) RNA in the peripheral blood mononuclear cells of HCV-infected patients following sustained virologic response
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Experimental Medicine"
DOI: 10.1007/s10238-022-00791-7
Abstract: It is unclear whether direct-acting antiviral drugs (DAAs) result in the complete eradication of HCV infection or whether some quantities of the virus may persist after achieving a sustained virologic response (SVR). Aim The aim… read more here.
Keywords: hcv rna; virologic response; rna peripheral; hcv ... See more keywords
Human peripheral blood mononuclear cells as an ex vivo model to study the host parasite interaction in Toxoplasma gondii.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental parasitology"
DOI: 10.1016/j.exppara.2020.108020
Abstract: Toxoplasma gondii is a parasite that can invade any cell in the human body. Here, we implemented and described an ex vivo model with human peripheral blood mononuclear cells (PBMCs) without using culture supplements/antibiotics and… read more here.
Keywords: pbmcs; infection; gondii; vivo model ... See more keywords
Characterization of a variant CD4 molecule in Japanese Black cattle.
Sign Up to like & getrecommendations! Published in 2020 at "Veterinary immunology and immunopathology"
DOI: 10.1016/j.vetimm.2020.110167
Abstract: Monoclonal antibodies (mAbs) that recognize cluster of differentiation (CD) molecules on lymphocytes are useful tools for the study of different lymphocyte subsets in flow cytometry (FCM) analysis. CD4 is a glycoprotein found on the surfaces… read more here.
Keywords: pbmcs; japanese black; characterization variant; mab ... See more keywords
Dielectric Signatures of Late Carcinoma Immune Cells Using MMTV-PyMT Mammary Carcinoma Models
Sign Up to like & getrecommendations! Published in 2024 at "ACS Omega"
DOI: 10.1021/acsomega.4c04210
Abstract: Peripheral blood mononuclear cells (PBMCs) are specialized immune cells produced from hematopoietic stem cells (HSC). They actively surveil for any signs of infection, foreign invaders, and abnormal or aberrant cells associated with diseases. Numerous inherent… read more here.
Keywords: immune cells; pbmcs; carcinoma; pymt ... See more keywords
Novel standardized method for extracellular flux analysis of oxidative and glycolytic metabolism in peripheral blood mononuclear cells
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-81217-4
Abstract: Analyzing metabolism of peripheral blood mononuclear cells (PBMCs) provides key opportunities to study the pathophysiology of several diseases, such as type 2 diabetes, obesity and cancer. Extracellular flux (XF) assays provide dynamic metabolic analysis of… read more here.
Keywords: pbmcs; flux analysis; analysis; method ... See more keywords
Comparative analysis and process optimization for manufacturing CAR-T using the PiggyBac system derived from cryopreserved versus fresh PBMCs
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-89686-7
Abstract: Chimeric antigen receptor T (CAR-T) therapy holds promise for cancer treatment but faces challenges with using fresh patient cells, including manufacturing failures and logistical hurdles. Cryopreserved peripheral blood mononuclear cells (PBMCs) offer a potential solution,… read more here.
Keywords: pbmcs; car; piggybac; process optimization ... See more keywords
High 4-1BB Expression in PBMCs and Tumor Infiltrating Lymphocytes (TILs) in Patients with Head and Neck Squamous Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "European Journal of Dentistry"
DOI: 10.1055/s-0043-1764419
Abstract: Abstract Objective 4-1BB is a costimulatory immune-activating molecule. Increased amounts of this protein have previously been found in the plasma of patients with oropharyngeal and oral cancer. Here, we focused on this molecule that functions… read more here.
Keywords: 1bb expression; hnscc; pbmcs; tumor ... See more keywords
P0068APABETALONE, A CLINICAL STAGE BET INHIBITOR, REDUCES THE PRO-INFLAMMATORY RESPONSE IN PBMCS FROM FABRY DISEASE PATIENTS ON ERT THERAPY
Sign Up to like & getrecommendations! Published in 2020 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfaa142.p0068
Abstract: Fabry disease (FD) is a rare X-linked recessive genetic disorder caused by mutations in the α-galactosidase A gene. Absence or defects of this lysosomal enzyme lead to globotriaosylceramide (Gb3) accumulation. Gb3 disrupts basic cellular metabolic… read more here.
Keywords: pbmcs; ert therapy; patients ert; gene ... See more keywords
Abstract 4: A novel humanized mouse model for study of T cells and NK cells in the tumor microenvironment
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4
Abstract: Humanized mouse models can be useful for in vivo preclinical evaluation of mechanisms underlying cancer immunotherapy. Most such models involve systemic engraftment of immunocompromised mice with human lymphoid and hematopoietic cells, often using normal donor… read more here.
Keywords: inoculation; model; cells tumor; pbmcs ... See more keywords
Interactions of Probiotics with the Immune Cells of Patients with COVID-19 Pneumonia
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Innate Immunity"
DOI: 10.1159/000545873
Abstract: Abstract Introduction: In severe COVID-19, excessive cytokine release may be driven by SARS-CoV-2. We investigated the modulatory effect of probiotics taking into consideration direct interaction with the immune gut cells. Methods: Fifty-five patients with confirmed… read more here.
Keywords: immune cells; pbmcs; cells patients; probiotics immune ... See more keywords